Results 81 to 90 of about 8,962 (171)

Successful Outcome of Autologous Stem Cell Transplantation for Relapsed or Refractory Germ Cell Tumors

International Journal of Hematology-Oncology and Stem Cell Research, 2018
Background: Treatment of choice for patients with refractory germ cell tumors (GCT) or recurrence after platinum containing chemotherapy regimens is not yet well recognized.
Seied Asadollah Mousavi, Negin Abedinzadeh, Leila Taj, Amir Kasaeian, Kamran Alimoghaddam, Mohammad Vaezi, Mohammad Zokaasadi, Hosein Kamranzdeh Fumani, Ardeshir Ghavamzadeh   +8 more
doaj  

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression

Cell Proliferation, EarlyView.
Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen, Xin Qi, Shanshan Qin, Jia Kang, Changhuo Cen, Miao Guo, Yang Gao, Mengyue Wang, Jiayi Li, Xiuhong Cui, Yanbo Wang, Lan Zhu, Fei Gao   +12 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

Testicular torsion in foals and stallions

Equine Veterinary Education, EarlyView.
Summary Testicular torsion is a rare condition in horses characterised by a change in the position of the testis due to the testicular mesentery twisting around its own axis; it can occur both when the testis is still in the abdominal cavity and when it has descended into the scrotum.
C. P. Bartmann
wiley   +1 more source

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Pattern‐based interpretation of SOX2 expression in ovarian teratomas: avoiding diagnostic pitfalls in the distinction between immature and mature neuroectodermal elements

Histopathology, EarlyView.
Ovarian immature teratoma grading may be confounded by mature neuroectodermal mimics. SOX2 labelled immature neuroepithelium but also mature ependymal and glial tissue, while SALL4 was negative in mature mimics and variably expressed in immature neuroepithelium.
Agnese Orsatti, Caterina Ravaioli, Marco Grillini, Eugenia Franchini, João Lobo, Andres M. Acosta, Veronica Mollica, Claudio Zamagni, Pierandrea De Iaco, Anna Myriam Perrone, Michelangelo Fiorentino, Giovanni Tallini, W. Glenn McCluggage, Costantino Ricci, Antonio De Leo   +14 more
wiley   +1 more source

Transplante de células-tronco hematopoéticas para tumores sólidos: recomendações do Consenso Brasileiro de Transplante de Medula Óssea Autologous hematopoietic stem cell transplantation in solid tumors: the Brazilian Consensus on Stem Cell Transplantation

Revista Brasileira de Hematologia e Hemoterapia, 2010
O transplante de células-tronco hematopoéticas autólogo permite o escalonamento de dose de drogas quimioterápicas e é uma estratégia atraente para tratamento de tumores sólidos, principalmente em doenças recaídas. Não há, no entanto, estudos randomizados
Décio Lerner, Leonardo J. Arcuri, Marta Colares   +2 more
doaj  

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source