Results 131 to 140 of about 69,351 (261)

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Metabolic profile and skeletal muscle as predictors of survival in testicular germ cell tumors. [PDF]

Oncologist
Barrón-Hernández A, Ríos-Rodríguez JA, García-Pacheco JA, Cuevas-Estrada B, De-la-Rosa S, Castro-Hernández C, Jiménez-Ríos MA, Sobrevilla-Moreno N, Santibáñez-Andrade M, González-Barrios R.   +9 more
europepmc   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Extracranial, Extragonadal Germ Cell Tumors: A Multicenter Australian Case Series. [PDF]

Asia Pac J Clin Oncol
Chow KVC, Conduit C, O'Haire S, Kuchel A, Wong S, Grimison P, Weickhardt A, Pranavan G, Lynam J, Bastick P, Goh J, Sengupta S, Smith A, Liow E, Campbell D, Wong M, Zlatic K, Gibbs P, Tran B, Gan CL.   +19 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Thromboembolic disease in testicular germ cell tumors-real-world evidence of three Portuguese institutions. [PDF]

Front Oncol
Albuquerque J, Oliveira M, Neto-Silva D, Margarido I, Correia J, Baptista C, Machete M, Bizarro R, Rato J, Godinho J, Teixeira JA, Passos-Coelho JL.   +11 more
europepmc   +1 more source

Gut microbiota‐mediated immune and metabolic dysregulation in coronary artery disease progression and prognosis

iMeta, EarlyView.
The gut microbiota has emerged as a metabolically active endocrine‐like organ with a crucial role in coronary artery disease (CAD), yet its contribution to adverse clinical outcomes remains incompletely understood. In this prospective cohort of 319 participants, we integrated metagenomic and metabolomic profiling with longitudinal follow‐up over a ...
Honghong Liu, Siqin Feng, Lifeng Liang, Muyun Tang, Yifei Wang, Yiyang Wang, Zhiyu Zhang, Haiping Xing, Chenhong Zhang, Ran Tian, Shuyang Zhang   +10 more
wiley   +1 more source

Retrospective Evaluation of Childhood Germ Cell Tumors: A Single-Center Experience. [PDF]

Children (Basel)
Selamioglu A, Kartal İ, Dincer OS, Tander B, Elli M, Gürsel SB, Acar S, Dagdemir A.   +7 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Machine learning based on radiomics for discriminating sellar region langerhans cell histiocytosis from germ cell tumors. [PDF]

Front Pediatr
Jiang H, Tong Z, Luo Y, Li Z, Shi L, Li L, Zhang Y.   +6 more
europepmc   +1 more source