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Pediatric germ cell tumors

Surgical Oncology, 2007
Pediatric germ cell tumors are a diverse group of neoplasms with variable clinical behaviors, depending upon the age and site of presentation. Most result from sporadic mutations, although environmental exposures and other genetic aberrations may play a role.
Zachary, Horton   +2 more
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Surgery for germ cell tumors

Seminars in Surgical Oncology, 2000
We performed a review of the current modalities of surgical treatment of malignant ovarian germ cell tumors by clinical stages and histological types. Stage IA dysgerminoma is performed with a unilateral salpingo-oophorectomy (USO) without chemotherapy. However, for Stage IB or IC patients with dysgerminoma, USO plus chemotherapy as a primary treatment
S, Sagae, R, Kudo
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Intracranial Germ Cell Tumors

Seminars in Neurology, 2023
AbstractIntracranial germ cell tumors are rare tumors occurring in adolescents and young adults, which include germinomas and non-germinomatous type germ cell tumors (NGGCT). In the past few decades, cooperative trial groups in Europe and North America have developed successful strategies to improve survival outcomes and decrease treatment-related ...
Teri Danielle You Ying, Yeoh   +4 more
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Neonatal Germ Cell Tumors

Current Pediatric Reviews, 2015
Excluding hemangiomas, germ cell tumors (GCTs) are the most common neoplasm in neonates, comprising a wide range of benign and malignant tumors with unique histological diversity. Although these tumors are relatively rare, antenatal ultrasonography has increased their detection before birth.
John A, Sandoval, Regan F, Williams
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Germ Cell Tumors

Surgical Clinics of North America, 2006
The category of germ cell tumors includes a broad array of histologic subtypes ranging from the benign, mature teratoma to the primitive, aggressive embryonal carcinoma (Box 1). These tumors share their origin in a primordial germ cell with multipotent capacity for differentiation along a variety of pathways.
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Germ cell tumors

Current Opinion in Oncology, 2005
This review provides an overview of some of the recent pre-clinical and clinical developments in germ cell tumors.Recent epidemiological studies highlight the variations in the geographic and ethnic distribution of germ cell tumors and the changing incidence of seminoma versus nonseminoma in the population. Additional studies are continuing to identify
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Pediatric germ cell tumor

Current Problems in Cancer, 1999
Malignant germ cell tumors are relatively uncommon, accounting for approximately 3% of all childhood malignancies. Occurring with an incidence of approximately 4 per million among children less than 15 years of age, they account for approximately 225 new cases per year in the United States. Germ cell tumors occur in both gonadal and extragonadal sites,
F J, Rescorla, P P, Breitfeld
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GERM CELL TUMORS OF THE OVARY

International Journal of Gynecological Pathology, 1982
During the review period, a number of papers were published reporting series of patients with malignant ovarian germ cell tumors and describing the increasingly successful worldwide trend observed in treatment of such patients. Publications dealing solely with the successful management of patients with pure dysgerminoma, using surgery followed by ...
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Germ-Cell Tumors of the Mediastinum

Advances in Anatomic Pathology, 1998
Germ-cell tumors occurring primarily in the mediastinum have been well recognized in the literature for many years. Unfortunately, most of what has been written on these tumors has been in the form of case reports and small series of cases, thus precluding a better understanding of their clinical and demographic features, as well as of their biologic ...
C A, Moran, S, Suster
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Chemotherapy for Germ Cell Tumors

Urologic Clinics of North America, 1987
With the advent of cisplatin-based chemotherapy and the incorporation of adjunctive surgery, 70 to 80 per cent of patients with advanced germ cell tumors are cured. Serum tumor markers are important diagnostically and prognostically and are necessary for monitoring response to therapy.
R J, Motzer, G J, Bosl
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