On the development of extragonadal and gonadal human germ cells [PDF]
Biology Open, 2016 Human germ cells originate in an extragonadal location and have to migrate to colonize the gonadal primordia at around seven weeks of gestation (W7, or five weeks post conception).
A. Marijne Heeren +8 more
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Germ cells are not required to establish the female pathway in mouse fetal gonads. [PDF]
PLoS ONE, 2012 The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary ...
Danielle M Maatouk +5 more
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The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. [PDF]
PLoS ONE, 2013 In mice, successful development and reproduction require that all cells, including germ cells, transition from a pluripotent to a differentiated state. This transition is associated with silencing of the pluripotency genes Oct4 and Nanog.
Leah M Okumura +2 more
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Origin and early history of the primordial germ‐cells in the chick [PDF]
, 1914 Charles H. Swift
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Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review [PDF]
Cell Journal, 2022 Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like ...
Shabnam Fayezi +3 more
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Metabolic pathways regulating the development and non-genomic heritable traits of germ cells
The Journal of Reproduction and Development, 2021 Metabolism is an important cellular process necessary not only for producing energy and building blocks for cells, but also for regulating various cell functions, including intracellular signaling, epigenomic effects, and transcription.
Yasuhisa MATSUI, Yohei HAYASHI
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In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Mouse embryonic stem (ES) cells can differentiate into female and male germ cells in vitro. Primate ES cells can also differentiate into immature germ cells in vitro.
Kaori Yamauchi +4 more
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Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis. [PDF]
PLoS ONE, 2009 In mammals, germ cells within the developing gonad follow a sexually dimorphic pathway. Germ cells in the murine ovary enter meiotic prophase during embryogenesis, whereas germ cells in the embryonic testis arrest in G0 of mitotic cell cycle and do not ...
Hui Li +4 more
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Frontiers in Cell and Developmental Biology, 2020 Formation of the hatching mouse blastocyst marks the end of preimplantation development, whereby previous cell cleavages culminate in the formation of three distinct cell lineages (trophectoderm, primitive endoderm and epiblast).
Giorgio Virnicchi +5 more
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Advances in Female Germ Cell Induction from Pluripotent Stem Cells
Stem Cells International, 2021 Germ cells are capable of maintaining species continuity through passing genetic and epigenetic information across generations. Female germ cells mainly develop during the embryonic stage and pass through subsequent developmental stages including ...
Maisumu Gulimiheranmu +2 more
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