Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus [PDF]
Biology, 2023 Germ line development and the origin of the primordial germ cells (PGCs) are very variable and may occur across a range of developmental stages and in several developmental contexts.
Roman P. Kostyuchenko +2 more
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Germ-line exon 21 EGFR V831H mutation in advanced NSCLC resistance to almonertinib: a case report [PDF]
Frontiers in OncologyBackgroundGerm-line EGFR mutations are rare, and their clinical significance, particularly regarding response to tyrosine kinase inhibitors (TKIs), remains poorly defined.
Daxia Cai +3 more
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Outcomes of germ line testing for children with hematologic malignancies undergoing hematopoietic cell transplantation [PDF]
Blood Advances: Recent studies reveal that a growing proportion of children with hematologic malignancies (HM) harbor germ line pathogenic or likely pathogenic variants (PV) in cancer-predisposing genes (CPG).
Arti S. Pandey +19 more
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Proteasomal subunit depletions differentially affect germline integrity in C. elegans
Frontiers in Cell and Developmental Biology, 2022 The 26S proteasome is a multi-subunit protein complex that is canonically known for its ability to degrade proteins in cells and maintain protein homeostasis.
Lourds Michelle Fernando +6 more
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Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
eLife, 2020 RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm.
Chih-Yung S Lee +5 more
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Frontiers in Ecology and Evolution, 2020 Evolutionary developmental biology focuses on understanding the origin and evolution of extant biological variation, and the genetic basis for this variation.
Arpita Kulkarni +3 more
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Editorial: Environmental factors affecting the germ line epigenome [PDF]
Frontiers in Endocrinology, 2023 Alfredo D. Vitullo +2 more
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Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes. [PDF]
PLoS ONE, 2013 Herein we demonstrate with PCR, immunodetection and reporter gene approaches that the widely used human Glial Fibrillary Acidic Protein (hGFAP)-Cre transgene exhibits spontaneous germ-line recombination activity in leading to deletion in brain, heart and
Jiong Zhang +8 more
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Nucleoporin98-96 function is required for transit amplification divisions in the germ line of Drosophila melanogaster. [PDF]
PLoS ONE, 2011 Production of specialized cells from precursors depends on a tightly regulated sequence of proliferation and differentiation steps. In the gonad of Drosophila melanogaster, the daughters of germ line stem cells (GSC) go through precisely four rounds of ...
Benjamin B Parrott +5 more
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Contrasting patterns of molecular evolution in metazoan germ line genes
BMC Evolutionary Biology, 2019 Background Germ lines are the cell lineages that give rise to the sperm and eggs in animals. The germ lines first arise from primordial germ cells (PGCs) during embryogenesis: these form from either a presumed derived mode of preformed germ plasm ...
Carrie A. Whittle, Cassandra G. Extavour
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