Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis. [PDF]
PLoS ONE, 2010 Drosophila oogenesis is especially well suited for studying stem cell biology, cellular differentiation, and morphogenesis. The small modifier protein ubiquitin regulates many cellular pathways.
Jan-Michael Kugler +2 more
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Females and males contribute in opposite ways to the evolution of gene order in Drosophila. [PDF]
PLoS ONE, 2013 An intriguing association between the spatial layout of chromosomes within nuclei and the evolution of chromosome gene order was recently uncovered. Chromosome regions with conserved gene order in the Drosophila genus are larger if they interact with the
Carlos Díaz-Castillo
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Scientific Reports, 2022 Proper reproduction depends on properly functioning gonads (ovaries and testes). Many xenobiotics, including heavy metals, can cause changes in somatic and germ line cells, thus damaging the reproductive capacity. The aim of this study was to investigate
Izabela Poprawa +6 more
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Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology
Frontiers in Cell and Developmental Biology, 2021 Aging animals display a broad range of progressive degenerative changes, and one of the most fascinating is the decline of female reproductive function.
Andrea Scharf +5 more
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An Emerging Role for Post-translational Modifications in Regulating RNP Condensates in the Germ Line
Frontiers in Molecular Biosciences, 2021 RNA-binding proteins undergo regulated phase transitions in an array of cell types. The phase separation of RNA-binding proteins, and subsequent formation of RNP condensates or granules, occurs during physiological conditions and can also be induced by ...
Jennifer A. Schisa, Mohamed T. Elaswad
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Identification of genes expressed in the hermaphrodite germ line of
BMC Genomics, 2009 Background Germ cells must progress through elaborate developmental stages from an undifferentiated germ cell to a fully differentiated gamete. Some of these stages include exiting mitosis and entering meiosis, progressing through the various stages of ...
Holt Robert A +9 more
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Germ Cell Responses to Stress: The Role of RNP Granules
Frontiers in Cell and Developmental Biology, 2019 The ability to respond to stress is critical to survival for animals. While stress responses have been studied at both organismal and cellular levels, less attention has been given to the effect of stress on the germ line. Effective germ line adaptations
Jennifer A. Schisa
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Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster, primordial germ cells are specified at the posterior pole of the very early embryo. This process is regulated by the posterior localized germ plasm that contains a large number of RNAs of maternal origin.
Ferenc Jankovics +6 more
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Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing
G3: Genes, Genomes, Genetics, 2019 The introduction of foreign DNA into cells and organisms has facilitated much of modern biological research, and it promises to become equally important in clinical practice.
Peter K. Nicholls +4 more
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Generation of germ cells from pluripotent stem cells in mammals
Reproductive Medicine and Biology, 2018 Background The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction
Masafumi Hayashi +3 more
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