Results 21 to 30 of about 4,398,636 (256)

RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line

G3: Genes, Genomes, Genetics, 2016
Complexes of RNA and RNA binding proteins form large-scale supramolecular structures under many cellular contexts. In Caenorhabditis elegans, small germ granules are present in the germ line that share characteristics with liquid droplets that undergo ...
Megan P. Wood, Angela Hollis, Ashley L. Severance, Megan L. Karrick, Jennifer A. Schisa   +4 more
doaj   +1 more source

Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies

Blood Advances, 2018
: Next-generation sequencing (NGS)–based targeted gene capture panels are used to profile hematopoietic malignancies to guide prognostication and treatment decisions.
Michael W. Drazer, Sabah Kadri, Madina Sukhanova, Sushant A. Patil, Allison H. West, Simone Feurstein, Dalein A. Calderon, Matthew F. Jones, Caroline M. Weipert, Christopher K. Daugherty, Adrián A. Ceballos-López, Gordana Raca, Mark W. Lingen, Zejuan Li, Jeremy P. Segal, Jane E. Churpek, Lucy A. Godley   +16 more
doaj   +1 more source

Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone

Journal of Developmental Biology, 2020
The C. elegans germ line and its gonadal support cells are well studied from a developmental genetics standpoint and have revealed many foundational principles of stem cell niche biology. Among these are the observations that a niche-like cell supports a
Kacy Gordon
doaj   +1 more source

Generation of a male common marmoset embryonic stem cell line DSY127-BV8VT1 carrying double reporters specific for the germ cell linage using the CRISPR-Cas9 and PiggyBac transposase systems

Stem Cell Research, 2020
BLIMP1 (PRDM1) and VASA (DDX4) play pivotal roles in the development of the germ cell linage. Importantly, these genes are specifically expressed in germ cells; BLIMP1 in primordial germ cells (PGCs) to early-stage gonocytes, and VASA in migration-stage ...
Sho Yoshimatsu, Tsukika Sato, Masafumi Yamamoto, Erika Sasaki, Mayutaka Nakajima, Mari Nakamura, Seiji Shiozawa, Toshiaki Noce, Hideyuki Okano   +8 more
doaj   +1 more source

The Ovary of Tubifex tubifex (Clitellata, Naididae, Tubificinae) Is Composed of One, Huge Germ-Line Cyst that Is Enriched with Cytoskeletal Components. [PDF]

PLoS ONE, 2015
Recent studies on the ovary organization and oogenesis in Tubificinae have revealed that their ovaries are small polarized structures that are composed of germ cells in subsequent stages of oogenesis that are associated with somatic cells.
Anna Z Urbisz, Łukasz Chajec, Piotr Świątek   +2 more
doaj   +1 more source

Restoration of Genetic Resources from Ehime Native Chicken via Transferred Primordial Germ Cells (PGCs)

The Journal of Poultry Science, 2001
This experiment was designed to produce chimeric chicken by transferring primordial germ cells (PGCs) of Ehime native chicken embryos to White Leghorn ones.
Hiroki Furuta, Keiji Kinoshita, Yoshizane Maeda, Noboru Fujihara   +3 more
doaj   +1 more source

Genetic and Epigenetic Regulation of Drosophila Oocyte Determination

Journal of Developmental Biology, 2023
Primary oocyte determination occurs in many organisms within a germ line cyst, a multicellular structure composed of interconnected germ cells. However, the structure of the cyst is itself highly diverse, which raises intriguing questions about the ...
Brigite Cabrita, Rui Gonçalo Martinho
doaj   +1 more source

Establishment of a pheasant (Phasianus colchicus) spermatogonial stem cell line for the production of interspecies germ line chimeras

Electronic Journal of Biotechnology, 2014
Background: Spermatogonial stem cells (SSCs) are important for the production of interspecies germ line chimeras. The interspecies germ cell transfer technique has been suggested as a way to conserve endangered birds.
Jeong Hyun Kim, Neelesh Sharma, Sung Woo Kim, Simrinder Singh Sodhi, Mrinmoy Ghosh, Nam Eun Kim, Raj Kumar Mongre, Sung Jong Oh, Dong Kee Jeong   +8 more
doaj   +1 more source

Primordial Germ Cell-Mediated Chimera Technology Produces Viable Pure-Line Houbara Bustard Offspring: Potential for Repopulating an Endangered Species [PDF]

, 2010
BACKGROUND: The Houbara bustard (Chlamydotis undulata) is a wild seasonal breeding bird populating arid sandy semi-desert habitats in North Africa and the Middle East.
Liu Chunhai, Baskar, Vijay, Saleem Shazia, Chang, Il-Kuk, Ulrich Wernery, Vijay Baskar, Shazia Saleem, Saleem, Shazia, Chunhai Liu, Il-Kuk Chang, Guerineche, Zhor, Baskar Vijay, Khazanehdari, Kamal A., Kamal A. Khazanehdari, Wernery, Renate, Wernery Renate, Darren K Griffin, Milstone, David S., Zhor Guerineche, Griffin Darren K., Liu, Chunhai, Kinne, Jörg, Khazanehdari Kamal A., Darren K. Griffin, Renate Wernery, Guerineche Zhor, Kamal A Khazanehdari, Jörg Kinne, Wernery, Ulrich, Wernery Ulrich, Kinne Jörg, Griffin, Darren K., Chang Il-Kuk   +32 more
core   +1 more source

Germ line landscape stratification defines distinct molecular and prognostic groups in therapy-related myeloid neoplasms

Blood Advances
: Exposure to chemotherapy (CT) and/or radiotherapy increases the risk of therapy-related myeloid neoplasms (t-MN), a heterogeneous group of disorders currently classified by treatment history rather than molecular features.
Oriol Calvete, Julia Mestre, Lorea Chaparro-González, Lucía Ruiz Pérez-Hita, Alba Mesa, Blanca Xicoy, Lurdes Zamora, Isabel Granada, Mar Mallo, Emili Cid, Estefania Mancini, Claudia Lozano, Laura Palomo, Pamela Acha, María Julia Montoro, Koji Sasaki, Courtney DiNardo, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Neus Torres-Hernández, Marta Santiago-Balsera, José Cervera, Gonzalo Maortua, Raquel de Paz, Martí Mascaró, Alfonso García Da Vila, Sara García-Ávila, Juan José Rodriguez-Sevilla, Leonor Arenillas, Beatriz Bellosillo, Rashmi Kanagal-Shamanna, Francesc Solé   +31 more
doaj   +1 more source