Results 41 to 50 of about 63,549 (243)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Gesellschaftliche Wandlung und Ihr Künstlerischer Ausdruck: Postmigrantische Literatur

open access: yesStudien zur Deutschen Sprache und Literatur
Der Mensch befindet sich permanent in Bewegung, auch wenn der erste Blick den Anschein erwecken könnte, dass die Grundform der menschlichen Existenz die Sesshaftigkeit ist.
Mahmut Karakuş
doaj   +1 more source

The Analysing of Hans Fallada’s Novel Every Man Dies Alone in the Context of Literary Sociology

open access: yesStudien zur Deutschen Sprache und Literatur, 2021
World War II and Hitler have brought severe consequences for many countries, as well as for Germany which started the war. The tragedy of the German people was often overshadowed by Hitler.
Ayhan Yavuz Özdemir
doaj   +1 more source

Two realisms: German realism and philosophy 1830-1890

open access: yes, 2002
Book synopsis: Although the importance of the interplay of literature and philosophy in Germany has often been examined within individual works or groups of works by particular authors, little research has been undertaken into the broader dialogue of ...
Walker, John
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Electronic Music from East Switzerland (via Germany)? Intermediality in Peter Weber’s Novel Die melodielosen Jahre (2007) [PDF]

open access: yes, 2022
This book aims to make an important contribution to the emerging field of German Pop Music Studies. The volume explores how pop music interacts transnationally with literature, politics, film, video and fine ...
Hurley, A
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

World Literary Histories as Rewritings of World Historiography

open access: yesComparative Literature: East & West, 2023
This essay approaches the question of rewriting world civilization through a sub-set of civilizational history, namely the historiography of world literature.
Thomas O. Beebee
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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