Results 141 to 150 of about 8,866 (208)

Dual‐Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures

Advanced Science, EarlyView.
A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng, Hufei Wang, Ming Li, Jianpeng Gao, Xiao Liu, Chuyue Zhang, Pengfei Chi, Bo Li, Yuan Xve, Daoyang Fan, Zheng Wang, Jianheng Liu, Xing Wang, Licheng Zhang   +13 more
wiley   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma. [PDF]

Nat Cancer
Barroux M, Househam J, Lakatos E, Ronel T, Baker AM, Salié H, Mossner M, Smith K, Kimberley C, Nowinski S, Berner A, Gunasri V, Borgmann M, Liffers S, Jansen M, Caravagna G, Steiger K, Slotta-Huspenina J, Weichert W, Zapata L, Giota E, Lorenzen S, Alberstmeier M, Chain B, Friess H, Bengsch B, Schmid RM, Siveke JT, Quante M, Graham TA.   +29 more
europepmc   +1 more source

AUTHENTIC TRANSLATION OF REPLY OF DEUTSCHER VERLEGERVEREIN TO RESOLUTION OF THE MEDICAL LIBRARY ASSOCIATION PROTESTING AGAINST THE HIGH PRICES OF GERMAN MEDICAL PUBLICATIONS.

Bulletin of the Medical Library Association, 2006
openaire   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion. [PDF]

Nat Commun
Wende M, Osbelt L, Eisenhard L, Lesker TR, Damaris BF, Mutukumarasamy U, Bielecka A, D H Almási É, Winter KA, Schauer J, Pfennigwerth N, Gatermann S, Schaufler K, Schlüter D, Galardini M, Strowig T.   +15 more
europepmc   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy. [PDF]

Genome Med
Lu IN, Müller-Miny L, Krekeler C, Cheung PF, Antonopoulou G, Jeibmann A, Schulte-Mecklenbeck A, Kerl K, Call S, Reicherts C, Bleckmann A, Stelljes M, Lenz G, Wiendl H, Zu Hörste GM, Grauer OM.   +15 more
europepmc   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance. [PDF]

Nat Commun
Kolb A, Kulis-Mandic AM, Klein M, Stastny A, Haist M, Votteler V, Weidenthaler-Barth B, Sinnberg T, Sucker A, Allies G, Albrecht LJ, Tasdogan A, Tuettenberg A, Gaida MM, Deppermann C, Stege H, Schadendorf D, Grabbe S, Schulze-Osthoff K, Kramer D.   +19 more
europepmc   +1 more source