Results 141 to 150 of about 133,668 (277)

Clonally expanded effector CD4⁺ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy. [PDF]

J Immunother Cancer
Giguelay AM, Maschmeyer P, Müller-Jensen L, Schinke C, Maierhof SK, Nambiar N, Meyer M, Huehnchen P, Boehmerle W, Endres M, Knauss S, Ludwig LS.   +11 more
europepmc   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Draft genome sequence of <i>Gleimia europaea</i> DSM 26657. [PDF]

Microbiol Resour Announc
Soghomonian A, Soghomonian M, Spunde A, Daum C, Gronow S, Göker M, Seshadri R, Maitra K.   +7 more
europepmc   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Nosocomial Outbreak of <i>Ralstonia pickettii</i> Infections Likely Linked to Saline Solutions in Germany from August 2023 to March 2024-Challenges in Medical Product-Related Outbreaks. [PDF]

Microorganisms
Sandfort M, von Laer A, Kampmeier S, Eichhorn I, Wolf SA, Driller M, Bajić V, Sedaghatjoo S, Fuchs S, Engelhart S, Mutters NT, Cónsul-Tejero EP, Zündorf J, Eckmanns T, Hogardt M, Haller S.   +15 more
europepmc   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Whole-genome sequencing of Lassa virus from dry blood spots: a comparative evaluation. [PDF]

Infect Dis Poverty
Bangura U, Davis C, Dahl A, Klemroth S, Thomson E, Magassouba N', Fichet-Calvet E.   +6 more
europepmc   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

REPLY OF MEDICAL LIBRARY ASSOCIATION TO GERMAN PUBLISHERS REGARDING GERMAN MEDICAL PUBLICATIONS.

, 1924
Charles Frankenberger, J. Christian Bay, Joanne A. P. Wilson   +2 more
openalex   +1 more source

DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease. [PDF]

Diabetologia
Sinke L, Delerue T, Wilson R, Lu X, Xia Y, Costeira R, Nasr MK, Beekman M, Franke L, Zhernakova A, Fu J, Gieger C, Herder C, Koenig W, Peters A, Ordovas JM, Dörr M, Grabe HJ, Nauck M, Bell JT, Teumer A, Snieder H, Waldenberger M, Slagboom PE, Heijmans BT.   +24 more
europepmc   +1 more source