Results 151 to 160 of about 9,094 (207)

Patient-reported outcomes (PROs) in clinical trials and in clinical practice: report from the XXI national conference of the Italian Association of Medical Oncology (AIOM). [PDF]

BMJ Oncol
Puccini A, Viscardi G, Ciani O, Efficace F, Piattelli A, Beretta GD, Petruzzelli D, Popoli P, De Lorenzo F, Longo F, Zibellini M, Gitto L, Brunello A, Maiello E, Servetto A, Pagliuca M, Raimondi A, Marandino L, Cinieri S, Iannelli E, Ripamonti CI, Bossi P, Numico G, Latiano T, Pinto C, Quaglini S, Locati L, Gussoni G, Mignone G, Carrera PM, Basch E, Di Maio M, Perrone F.   +32 more
europepmc   +1 more source

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

An Epidemic of Respiratory and Ocular Infections Caused by the Reemergence of a Recombinant Human Adenovirus, the Novel Type HAdV-B114 (P7H3F3). [PDF]

J Med Virol
Ganzenmueller T, Wolf M, Wolfram L, Gkioule C, Steinbrück L, Heim A.   +5 more
europepmc   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target. [PDF]

Nat Commun
Llaó-Cid L, Wong J, Fernandez Botana I, Paul Y, Wierz M, Pilger LM, Floerchinger A, Tan CL, Gonder S, Pagano G, Chazotte M, Bestak K, Schifflers C, Iskar M, Roider T, Czernilofsky F, Bruch PM, Mallm JP, Cosma A, Campton DE, Gerhard-Hartmann E, Rosenwald A, Colomer D, Campo E, Schapiro D, Green EW, Dietrich S, Lichter P, Moussay E, Paggetti J, Zapatka M, Seiffert M.   +31 more
europepmc   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension. [PDF]

Pulm Circ
Reiser AE, Thiersch M, Gassmann M, Muckenthaler MU, Geiser T, Lichtblau M, Ulrich S.   +6 more
europepmc   +1 more source

TaPPR13, a Pentatricopeptide Repeat Protein Gene Activated by TaBZR2, Confers Drought Stress Tolerance by Enhancing the Antioxidant Defense System and Promoting Retrograde Signaling in Wheat (Triticum aestivum)

Advanced Science, EarlyView.
TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou, Wei‐Jun Zheng, Lei Zheng, Jing‐Yue Wang, Shuang‐Xi Zhang, Ji‐Tong Wei, Shu‐Hui Yang, Yuan‐Chen Jiao, Wen‐Jing Cheng, Tai‐Fei Yu, Xiao‐Fei Ma, Jing‐Na Ru, Yong‐Wei Liu, Xin‐You Cao, Jun Chen, Yong‐Bin Zhou, Ming Chen, Li‐Hui Li, You‐Zhi Ma, Xiao‐Jun Nie, Zhao‐Shi Xu   +20 more
wiley   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

High quality genome assembly and annotation (v1) of the eukaryotic freshwater microalga Coccomyxa elongata SAG 216-3b. [PDF]

G3 (Bethesda)
Kraege A, Chavarro-Carrero E, Schnell E, Heilmann-Heimbach S, Becker K, Köhrer K, Huettel B, Sargheini N, Schiffer P, Waldvogel AM, Thomma BPHJ, Rovenich H.   +11 more
europepmc   +1 more source