Results 171 to 180 of about 41,715 (245)

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

AUTHENTIC TRANSLATION OF REPLY OF DEUTSCHER VERLEGERVEREIN TO RESOLUTION OF THE MEDICAL LIBRARY ASSOCIATION PROTESTING AGAINST THE HIGH PRICES OF GERMAN MEDICAL PUBLICATIONS.

Bulletin of the Medical Library Association, 2006
openaire   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

CSF single-cell RNA sequencing reveals clonally expanded CD4⁺stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

Barman S, Räuber S, Eisenhut K, Esser D, van Duijn M, Scharf M, Herrera-Rivero M, Disse P, Jonas M, Pul D, Heming M, Müller-Miny L, Paunovic M, Strippel C, Haholu E, Kaufmann E, Dargvainiene J, Kahl S, Ringelstein M, Bindels E, Wiendl H, Stoecklein NH, Fischer J, Goebels N, Komorowski L, Roden M, Rossi A, Stoll M, Meuth SG, Titulaer MJ, Leypoldt F, Meyer zu Hörste G, Thaler F, Melzer N, cooperation with the EMC-AIE Study group, the German Network for Research on Autoimmune Encephalitis.   +35 more
europepmc   +1 more source

One-year survival after critical care as a decision basis for advance care directives in general medicine: Real word data analysis of 149,144 patients. [PDF]

PLoS One
Unger C, Werner F, Engel B, Kühlein T, Schulz C, Kümpel C, Gorkotte J, Hueber S.   +7 more
europepmc   +1 more source

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Understanding stigma: The experiences of people with drug-sensitive pulmonary tuberculosis in Rawalpindi, Pakistan. [PDF]

PLoS One
Stein R, Fastenau A, Aman H, Ortuño-Gutiérrez N, Schmotzer C, Unterkircher SC, Pilot E.   +6 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer. [PDF]

Nat Commun
Zuljan E, von der Emde B, Piwonski I, Pestana A, Klinghammer K, Mock A, Horak P, Heining C, Klauschen F, Pretzell I, Boerries M, Brandts CH, Kreutzfeldt S, Teleanu MV, Hübschmann D, Morris LGT, Heiland M, Keller U, Conrad T, Glimm H, Fröhling S, Ochsenreither S, Keilholz U, Blanc E, Beule D, Rieke DT.   +25 more
europepmc   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source