Results 201 to 210 of about 343,979 (290)

Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies <i>SMARCAL1</i> as a Novel Osteosarcoma Predisposition Gene. [PDF]

J Clin Oncol
Oak N, Chen W, Blake A, Harrison L, O'Brien M, Previti C, Balasubramanian G, Maass K, Hirsch S, Penkert J, Jones BC, Schramm K, Nathrath M, Pajtler KW, Jones DTW, Witt O, Dirksen U, Li J, Sapkota Y, Ness KK, Guenther LM, Pfister SM, Kratz C, Wang Z, Armstrong GT, Hudson MM, Wu G, Autry RJ, Nichols KE, Sharma R.   +29 more
europepmc   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN. [PDF]

Leukemia
Kapahnke K, Plenge T, Klaus T, Gupta MK, Anand D, Önder TT, Perner B, Schnöder TM, Thol FR, Damm F, Heidel FH, Perner F.   +11 more
europepmc   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits. [PDF]

Breast
Witt D, Sturm M, Stäbler A, Menden B, Ruisinger L, Bosse K, Gruber I, Hartkopf A, Gauß S, Demidov G, Casadei N, Atienza EB, Mehnert K, Witt J, Gross C, Schütz L, Schroeder C, Ossowski S, Dufke A, Haack TB, Riess O, Faust U.   +21 more
europepmc   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials. [PDF]

Ann Intensive Care
Mewes D, Weber-Carstens S, Rubarth K, Boie SD, Spies C, Kramer A, Fielitz J, Wollersheim T, Ananthasubramaniam B, Braune F, Hancke L, Spies L, Balzer F, Engelhardt LJ.   +13 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Preterm birth, socioeconomic status, and white matter development across childhood. [PDF]

Dev Cogn Neurosci
Mckinnon K, Blesa Cábez M, Thye M, Abel S, Smikle R, Skelton J, Jiménez-Sánchez L, Vaher K, Sullivan G, Corrigan A, Barclay G, Jardine C, Hamilton I, McIntyre D, Chua YW, Amir R, Quigley AJ, Battersby C, Tsanas A, Batty GD, Reynolds RM, Cox SR, Whalley HC, Thrippleton MJ, Bastin ME, Richardson H, Boardman JP.   +26 more
europepmc   +1 more source