Results 201 to 210 of about 351,337 (287)

Benchmarking speech-to-text robustness in noisy emergency medical dialogues: an evaluation of models under realistic acoustic conditions. [PDF]

JAMIA Open
Moser D, Stanic N, Sariyar M.
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Advancing Evidence-Based Nursing: The Updated German Expert Standard on Continence Promotion. [PDF]

Healthcare (Basel)
Pöhner J, Kaiser J, Krebs M, Büscher A, Hayder-Beichel D.   +4 more
europepmc   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Correction: Toward a Domain-Overarching Metadata Schema for Making Health Research Studies FAIR (Findable, Accessible, Interoperable, and Reusable): Development of the NFDI4Health Metadata Schema.

JMIR Med Inform
Abaza H, Shutsko A, Klopfenstein SAI, Vorisek CN, Schmidt CO, Brünings-Kuppe C, Clemens V, Darms J, Hanß S, Intemann T, Jannasch F, Kasbohm E, Lindstädt B, Löbe M, Nimptsch K, Nöthlings U, Ocanto MG, Osei TB, Perrar I, Peters M, Pischon T, Sax U, Schulze MB, Schwarz F, Schwedhelm C, Thun S, Waltemath D, Zeleke AA, Müller W, Golebiewski M.   +29 more
europepmc   +1 more source

BEscreen: a versatile toolkit to design base editing libraries. [PDF]

Nucleic Acids Res
Schneider PG, Liu S, Bullinger L, Ostendorf BN.   +3 more
europepmc   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Epigenetic risk stratification in juvenile myelomonocytic leukemia by targeted methylation analysis of the BMP4 locus. [PDF]

Clin Epigenetics
Ghanjati F, Heck A, Lebrecht D, Nöllke P, Andresen F, Rotari N, Schoof M, Schönung M, Lipka DB, Dworzak M, De Moerloose B, Sukova M, Hasle H, Jahnukainen K, Malone A, Masetti R, Buechner J, Ussowicz M, Catala A, Turkiewicz D, de Haas V, Schmugge M, Erlacher M, Niemeyer CM, Flotho C.   +24 more
europepmc   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Health-economic evaluation of statins versus lifestyle changes for cardiovascular disease prevention. [PDF]

PLoS One
Gandjour A.
europepmc   +1 more source