Results 171 to 180 of about 2,724,689 (240)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Correction: Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer. [PDF]

Cell Commun Signal
Ramasubramanian S, Öllinger R, Eberhagen C, Zischka H, Schmid RM, Einwächter H.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Vitiligo in the Digital Spotlight: Retrospective Longitudinal Study in Germany. [PDF]

JMIR Form Res
Müller E, Gasteiger C, Böhm M, Pliszewski G, Rauch L, Biedermann T, Zink A.   +6 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Epidemiology, treatment patterns, and survival outcomes of patients with mantle cell lymphoma in Germany: a retrospective analysis of administrative claims data. [PDF]

Ann Hematol
Friedel H, Hennies N, Zschocke J, Hosseini SK, Bölz S, Bocuk D, Wilhelm S, Zaba O, Buske C.   +8 more
europepmc   +1 more source

Germany (Federal Republic of Germany)

, 2023
Detterbeck, Klaus, Griffiths, Ann, Chattopadhyay, Rupak, Light, John, Stieren, Carl   +4 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Stereotactic body radiotherapy in patients with bone oligometastases from breast cancer - results from a European multicenter cohort study. [PDF]

Clin Transl Radiat Oncol
Schäfer S, Seiler I, Kästner L, Meents J, Slavik M, Burkon P, Loi M, Bonomo P, von Wachter C, Balermpas P, Schunn AS, Drabke S, Holy R, Klischies K, Wittenstein O, Willner J, Baehr A, Bank P, Partl R, Mader T, Frerker B, Lohaus F, Ehret F, Trommer M, Gkika E, Rühle A, Guckenberger M, Moustakis C, Brunner T, Blanck O, Heggemann JB, Nicolay NH, Nägler F.   +32 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source