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Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus. [PDF]
Cell RepSanchez GM +12 more
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Accelerated involution of germinal center in palatine tonsils in IgA nephropathy. [PDF]
PLoS OneUeda H +9 more
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Advances in Experimental Medicine and Biology, 2020
Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
Chuanxin Huang
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Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
Chuanxin Huang
openaire +3 more sources
Immunological Reviews, 1997
Summary: Using a set of surface markers Including igD and CD38, human tonsillar B cells were classified into discrete subpopulations. Molecular and functional analysis allowed us to identify: i) two sets of naive B cells (Bml and Bm2); ii) germinal center founder cells (Bm2′); iii) an obscure population of germinal center B cells, displaying a high ...
Liu, Yong-Jun, Arpin, Christophe
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Summary: Using a set of surface markers Including igD and CD38, human tonsillar B cells were classified into discrete subpopulations. Molecular and functional analysis allowed us to identify: i) two sets of naive B cells (Bml and Bm2); ii) germinal center founder cells (Bm2′); iii) an obscure population of germinal center B cells, displaying a high ...
Liu, Yong-Jun, Arpin, Christophe
openaire +2 more sources
Current Opinion in Hematology, 2001
The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
L J, McHeyzer-Williams +2 more
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The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
L J, McHeyzer-Williams +2 more
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Monocytes asphyxiate germinal centers
Immunity, 2022Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et al. (2022) uncover a mechanism by which Salmonella recruits Sca-1+ monocytes to germinal centers and impairs ...
Yuke, He, Carola G, Vinuesa
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Annual Review of Immunology, 1994
Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Invasion of the germinal centers
Cell, 2023After vaccination or infection, long-lived germinal centers can produce antibodies with high affinity and specificity against pathogens. In this issue of Cell, de Carvalho et al. and Hägglöf et al. show that naive B cells can invade germinal centers, replacing B cells that entered early and changing features of antibody production.
Daniel P, Maurer, Aaron G, Schmidt
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