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The dynamic structure of the germinal center
Immunology Today, 1998Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur.
S A, Camacho +2 more
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Germinal centers develop oligoclonally
European Journal of Immunology, 1987AbstractAs part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development).
Kroese, FGM +3 more
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How to Simulate a Germinal Center
2017Germinal centers host a mini-evolutionary environment where B cells can mutate their receptor and be selected depending on its affinity to target antigens in a process called affinity maturation. Starting from founder cells with a weak B cell receptor affinity, germinal centers release output cells as antibody-secreting cells or memory cells with a ...
Philippe A, Robert +3 more
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Continuous germinal center invasion contributes to the diversity of the immune response
Cell, 2023Charlotte Viant
exaly
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Cell, 2023Tri Giang Phan
exaly
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Cell, 2022Katlyn Lederer +2 more
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Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
Journal of Experimental Medicine, 2021Juhee Pae +2 more
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