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Critical Reviews in Immunology, 2004
The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L, Wolniak +2 more
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The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L, Wolniak +2 more
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Annual Review of Immunology, 1994
Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Complement-in’ the germinal center response
Nature Immunology, 2021B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
Marcus James Robinson +2 more
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Getting toGether in Germinal centers
Science Immunology, 2021Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Liat Stoler-Barak, Ziv Shulman
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2020
Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
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Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
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To ‘B’ or not to ‘B’ a germinal center?
Immunology Today, 1997Abstract Under certain pathological conditions, germinal centers (GCs) form in many atypical sites, such as the stomach, lung and synovial joints. Thus, understanding the cellular and molecular interactions leading to a GC response is relevant not only for protective immunity but also for possible therapeutic strategies.
M H, Kosco-Vilbois +3 more
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The life and death of the germinal center
Annals of Diagnostic Pathology, 2020The formation, development and dissolution of germinal centers is a major part of immune system function. It is important to differentiate neoplastic processes from follicular hyperplasia and regressive follicular changes. Better understanding of germinal center development and dissolution also provides diagnostic clues to the underlying pathologic ...
Eric, Gars +4 more
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Immunosenescence and germinal center reaction
Immunological Reviews, 1997Summary: Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self‐reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged.
B, Zheng +3 more
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The chilling origin of germinal centers
Science Immunology, 2023Germinal center–like structures have been identified in ectothermic vertebrates, establishing germinal centers as a universal component of humoral immunity (see related Research Article by Shibasaki et al. )
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Repulsive behavior in germinal centers
Science, 2017B cell–T cell interactions are terminated by EPH receptors and ...
G. Leandros Moschovakis +1 more
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