Results 291 to 300 of about 72,003 (345)

Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development. [PDF]

Immunity
Marina-Zárate E, Sutton HJ, Lopez PG, Altheide TK, Bick M, Burton I, Ben-Akiva E, Kaczmarek Michaels K, Hyacinth K, Healy BS, Lim D, Hangartner L, Burton DR, Carnathan DG, Silvestri G, Schief WR, Irvine DJ, Crotty S.   +17 more
europepmc   +1 more source

Clinico-pathologic Profile of Filipino Patients Diagnosed with Diffuse Large B-Cell Lymphoma, Germinal Center or Non-germinal Center Subtype Treated in a Public Tertiary Hospital from 2016 to 2021. [PDF]

Acta Med Philipp
Cancio JEG, Damian KB, Villanueva EQ, Lucero JAC, Talavera ERF.   +4 more
europepmc   +1 more source

CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation. [PDF]

Nat Commun
Zhao Y, Gong S, Yang Y, Lu Y, Bai J, Liu M, Bai W, Dong J.   +7 more
europepmc   +1 more source

Accelerating Vaccine Adjuvant Screening: Early Follicular Dendritic Cell and Germinal Center B Cell Biomarkers Predict Protective Efficacy. [PDF]

Vaccines (Basel)
Zhong Y, Chen M, Lin H, Liu Z, Zhang S, He Y, Wang B.   +6 more
europepmc   +1 more source

Foxp3+ follicular regulatory T cells control the germinal center response

Nature Medicine, 2011
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self tolerance.
Michelle A Linterman, Wim Pierson, Axel Kallies   +2 more
exaly   +3 more sources

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Invasion of the germinal centers

Cell, 2023
After vaccination or infection, long-lived germinal centers can produce antibodies with high affinity and specificity against pathogens. In this issue of Cell, de Carvalho et al. and Hägglöf et al. show that naive B cells can invade germinal centers, replacing B cells that entered early and changing features of antibody production.
Daniel P, Maurer, Aaron G, Schmidt
openaire   +2 more sources

Selection in the germinal center

Current Opinion in Immunology, 2020
Germinal centers (GCs) are well known for their important role in shaping the secondary B cell repertoire to generate antibodies capable of binding with high-affinity and specificity to foreign antigens. Somatic hypermutation of the Ig variable region genes in GC B cells represents a highly efficient mechanism for generating new antibody variants with ...
Angelica Wy, Lau, Robert, Brink
openaire   +2 more sources

Germinal center development

Immunological Reviews, 1997
Summary: Using a set of surface markers Including igD and CD38, human tonsillar B cells were classified into discrete subpopulations. Molecular and functional analysis allowed us to identify: i) two sets of naive B cells (Bml and Bm2); ii) germinal center founder cells (Bm2′); iii) an obscure population of germinal center B cells, displaying a high ...
Liu, Yong-Jun, Arpin, Christophe
openaire   +2 more sources

The germinal center reaction

Journal of Allergy and Clinical Immunology, 2010
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy ...
Dominique, Gatto, Robert, Brink
openaire   +2 more sources

Germinal center reaction

Current Opinion in Hematology, 2001
The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
L J, McHeyzer-Williams, D J, Driver, M G, McHeyzer-Williams   +2 more
openaire   +2 more sources