Results 191 to 200 of about 234,487 (302)

Novel Co-Occurrence of Germline <i>EGFR</i> p.V843I and Somatic <i>EGFR</i> Exon 19 Deletion in NSCLC: Insights into Reduced Sensitivity to EGFR-TKIs. [PDF]

Int J Mol Sci
Resen K, Melchior LC, Sørensen JB, Wadt KAW, Urbanska EM, Santoni-Rugiu E.   +5 more
europepmc   +1 more source

Quantifying extra‐lesional interhemispheric cortical asymmetry in focal cortical dysplasia type II

Epilepsia Open, EarlyView.
Abstract Objective Focal cortical dysplasia type II (FCDII) is a cortical malformation representing a common cause of surgically treatable drug‐resistant epilepsy. We studied whether FCDII disrupts normal structural interhemispheric asymmetry beyond the lesion location and quantified these asymmetries derived from structural magnetic resonance imaging (
Faezeh Heidari, Mastaneh Torkamani‐Azar, Jussi Tohka, Reetta Kälviäinen   +3 more
wiley   +1 more source

Comprehensive evaluation of structural variation detection for germline and somatic analysis with long-read sequencing data. [PDF]

Brief Bioinform
Shi H, Lin Y, Liu D, Wu H, Mat Isa AN, Wei L, Zou Q, Chen X.   +7 more
europepmc   +1 more source

Germline Imprinting [PDF]

Developmental Cell, 2004
openaire   +1 more source

Ethics of germline genome editing to prevent genetic diseases from an Islamic perspective

In 2018, Dr He Jiankui announced he created the world's first genome-edited babies (BioNews 977), which sparked a call for a five-year moratorium on germline genome editing.
Chin, Alexis Heng Boon, Muhsin, Sayyed Mohamed   +1 more
core  

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

Beyond the variant: hereditary cancer awareness in the multi-omics era. [PDF]

Hereditas
Kazi JU, Massoumi R.
europepmc   +1 more source

Germline Mutation [PDF]

, 2020
openaire   +1 more source

Modifying germlines – or not? [PDF]

Nature Cell Biology, 2004
openaire   +1 more source

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source