Results 201 to 210 of about 234,487 (302)

Predicting Oral Cancer From Precursor Lesions: The Case for a Standardized Framework of Analysis to Improve Prediction Modeling

Head &Neck, EarlyView.
ABSTRACT Oral Cancer often occurs from the transformation of precursor lesions, and this offers an opportunity for early detection. Current methods to assess risk of precursor lesion progression to oral cancer incompletely predict risk. A multimodal framework that leverages machine learning is needed to improve prediction.
Michael E. Troka, James C. Gates
wiley   +1 more source

Incidence of Germline Genetic Variants in Patients with a Urinary Tract Cancer and Association with Outcomes. [PDF]

Eur Urol Oncol
Kamau K, Byrne L, Goradia R, Sundi D, Meng L, Yang Y, Gauntner TD, Wang SJ, Clinton SK, Mortazavi A, Stover DG, Sood A, Collier KA.   +12 more
europepmc   +1 more source

Real-World Germline Testing Patterns and Clinical Implications of HRR-Associated Germline Variants in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancers (Basel)
Abad CB, Deza DC, Campillo FM, Fuente NP, Egea SER, Caballero LG, Delgado CS, Molina CAR, Gallart MDM, Ferrández MJA, Pons PG, Ramírez SEC, Ruiz MG, Marques EP, Pazo Cid RA.   +14 more
europepmc   +1 more source

Germline genomic testing to assess the suitability of stem cell donors in the treatment of haematological malignancy: clinical ethics commentary. [PDF]

J Med Ethics
Carley H, Sahan K, Hanson H, Snape K, Westbury S, Parker MJ, Lucassen AM.   +6 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

A Lynch Syndrome Family With Germline <i>MLH1</i> c.931A>G Showing Preserved Tumor MMR Immunostaining but MSI-H Status: A Case Report. [PDF]

Clin Case Rep
Cai J, Li Z, Han T, Guo Y, Du Y, Liu D, Liu X.   +6 more
europepmc   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas. [PDF]

Endocr Pathol
Purnaghshband H, Tuzlali E, Deka KB, Bruce JP, Farncombe KM, Gillies B, Prokopec SD, Pugh T, Redmond S, Redondo L, Wang H, Ezzat S, Mete O, Kim RH.   +13 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

VAF-tumor content graph: a simple visual framework for interpreting hereditary cancer variants and supporting genetic counseling in tumor-only sequencing. [PDF]

J Hum Genet
Kashima M, Tsubamoto H, Ueda T, Kinjo C, Okada C, Muroi Y, Ueda M, Otsuki T, Kataoka K, Nagahashi M, Matsuda I, Sawai H, Kijima T, Miyazaki A.   +13 more
europepmc   +1 more source