Results 41 to 50 of about 234,487 (302)

Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis

Journal of Developmental Biology, 2016
The germ cell lineage in Xenopus is specified by the inheritance of germ plasm that assembles within the mitochondrial cloud or Balbiani body in stage I oocytes. Specific RNAs, such as nanos1, localize to the germ plasm. nanos1 has the essential germline
Tristan Aguero, Yi Zhou, Malgorzata Kloc, Patrick Chang, Evelyn Houliston, Mary Lou King   +5 more
doaj   +1 more source

Prevalence of Lynch syndrome in women with mismatch repair‐deficient ovarian cancer

Cancer Medicine, 2021
Background There are limited data on the prevalence of Lynch syndrome (LS) in women with primary ovarian cancer with mismatch repair deficiency (MMR‐D) by immunohistochemistry (IHC). Materials and Methods Three hundred and eight cases of primary ovarian,
Rachel Hodan, Kerry Kingham, Kristina Cotter, Ann K. Folkins, Allison W. Kurian, James M. Ford, Teri Longacre   +6 more
doaj   +1 more source

Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

eLife, 2021
In multicellular organisms, sexual reproduction requires the separation of the germline from the soma. In flowering plants, the female germline precursor differentiates as a single spore mother cell (SMC) as the ovule primordium forms.
Elvira Hernandez-Lagana, Gabriella Mosca, Ethel Mendocilla-Sato, Nuno Pires, Anja Frey, Alejandro Giraldo-Fonseca, Caroline Michaud, Ueli Grossniklaus, Olivier Hamant, Christophe Godin, Arezki Boudaoud, Daniel Grimanelli, Daphné Autran, Célia Baroux   +13 more
doaj   +1 more source

Modulatory impact of Bifidobacterium longum subsp. longum BL21 on the gut–brain–ovary axis in polycystic ovary syndrome: insights into metabolic regulation, inflammation mitigation, and neuroprotection

mSphere
This study evaluates the efficacy of Bifidobacterium longum subsp. longum BL21 in mitigating symptoms of polycystic ovarian syndrome (PCOS) in DHT-induced PCOS model mice. It focuses on BL21’s role in modulating metabolic dysregulation, inflammation, and
Yao Dong, Shengnan Yang, Shu Zhang, Yuan Zhao, Xinlan Li, Mei Han, Zhonghui Gai, Kang Zou   +7 more
doaj   +1 more source

What Is Lost in the Weismann Barrier?

Journal of Developmental Biology, 2020
The Weismann barrier has long been regarded as a basic tenet of biology. However, upon close examination of its historical origins and August Weismann’s own writings, questions arise as to whether such a status is warranted.
Abigail P. Bline, Anne Le Goff, Patrick Allard   +2 more
doaj   +1 more source

Timeless or tainted? The effects of male ageing on seminal fluid

Frontiers in Ecology and Evolution, 2023
Reproductive ageing can occur due to the deterioration of both the soma and germline. In males, it has mostly been studied with respect to age-related changes in sperm. However, the somatic component of the ejaculate, seminal fluid, is also essential for
Claudia Fricke, Krish Sanghvi, Mischa Emery, Ina Lindenbaum, Stuart Wigby, Steven A. Ramm, Steven A. Ramm, Irem Sepil   +7 more
doaj   +1 more source

Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy

Frontiers in Pharmacology, 2020
Neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery is the standard of care for patients with Locally Advanced Rectal Cancer (LARC).
Elena De Mattia, Rossana Roncato, Elisa Palazzari, Giuseppe Toffoli, Erika Cecchin   +4 more
doaj   +1 more source

Germline MBD4 deficiency causes a multi-tumor predisposition syndrome [PDF]

, 2022
We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4.
Nuria Lopez-Bigas, Trevor Graham, Yael Goldberg, Andrea Sottoriva, Lynn Martin, Judith E. Grolleman, Sara Galavotti, Nicola Lander, Simone A.M. van der Biezen, Laura E. Thomas, Laura Chegwidden, Edward H. Arbe-Barnes, David J. Adams, William Cross, Kitty Sherwood, Demetra Georgiou, Florentia Fostira, Constantinos Deltas, Dagmara Dymerska, Christoffer Flensburg, Richard Houlston, Tom van Wezel, Huw Thomas, Khalid Mahmood, Lilian Vreede, Mark Clendenning, Aleksandar J. Dimovski, Edward Chew, Rachel S. van der Post, Boris Noyvert, Ashish Bajel, Daniel Chubb, Judith Pagan, Celina Whalley, Rebekah Truscott, Claire Palles, David Church, Hannah D. West, Michael Christie, Giulio Caravagna, Andreas J. Gruber, Clare Turnbull, Ben Kinnersley, Claudia Arnedo-Pac, Jenny C. Taylor, Erik A.M. Jansen, Helen Curley, Mathijs Sanders, Jan Lubinski, Anna Frangou, Jürgen Weitz   +50 more
core   +1 more source

SMAD3 and HIF-1α orchestrate metabolic transition to aerobic glycolysis as a critical prerequisite for spontaneous reprogramming of spermatogonial stem cells

Stem Cell Research & Therapy
Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why the addition of epidermal growth factor (EGF), leukemia inhibitory ...
Yihui Cai, Jian Wen, Hongyang Liu, Rui Wei, Xiaoxiao Li, Yao Dong, Keren Cheng, Kang Zou   +7 more
doaj   +1 more source

A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

eLife, 2016
The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution.
Michelle A Carmell, Gregoriy A Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C van Wolfswinkel, Kyomi J Igarashi, Daniel W Bellott, Michael Nefedov, Peter W Reddien, George C Enders, Vladimir N Uversky, Craig C Mello, David C Page   +12 more
doaj   +1 more source