Results 21 to 30 of about 234,487 (302)
Androgen promotes differentiation of PLZF+ spermatogonia pool via indirect regulatory pattern
Cell Communication and Signaling, 2019 Background Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR).
Jingjing Wang +10 more
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WormBook, 2006 The completion of the C. elegans genome sequence permits the comprehensive examination of the expression and function of genes. Annotation of virtually every encoded gene in the genome allows systematic analysis of those genes using high-throughput assays, such as microarrays and RNAi.
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The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans
Frontiers in Cell and Developmental Biology, 2023 RNA passed from parents to progeny controls several aspects of early development. The germline of the free-living nematode Caenorhabditis elegans contains many families of evolutionarily conserved RNA-binding proteins (RBPs) that target the untranslated ...
Mennatallah M. Y. Albarqi, Sean P. Ryder
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Atypical ATMs: Broadening the phenotypic spectrum of ATM-associated hereditary cancer
Frontiers in Oncology, 2023 Heterozygous, loss-of-function germline variants in ATM have been associated with an increased lifetime risk of breast, pancreas, prostate, stomach, ovarian, colorectal, and melanoma cancers.
Nicholas A. Borja +6 more
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Germline‐targeting immunogens [PDF]
Immunological Reviews, 2017 SummaryIn 2009, Dimitrov's group reported that the inferred germline (iGL) forms of several HIV‐1 broadly neutralizing antibodies (bNAbs) did not display measurable binding to a recombinant gp140 Env protein (derived from the dual‐tropic 89.6 virus), which was efficiently recognized by the mature (somatically mutated) antibodies.
Leonidas, Stamatatos +2 more
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On the origin of the human germline [PDF]
Development, 2018 ABSTRACT In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study because of the technical and ethical constraints that limit direct studies on human embryos. In recent
Kobayashi, Toshihiro, Surani, M Azim
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The American Journal of Bioethics, 2020 Bryan Cwik shows the importance of asking questions such as: what is goal of a given germline intervention? Does the specific method of intervention have its own idiosyncratic ethical texture? Are there alternative means of producing the same end that are less risky and less morally contentious?
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Frontiers in Immunology, 2020 We have previously shown that the sequence of the immunoglobulin diversity gene segment (DH) helps dictate the structure and composition of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3).
Mohamed Khass +6 more
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Germline-optimized Cas9 improves editing efficiency.
, 2021 A. Gene diagrams representing the germline optimized Pmex-5::Cas9 MosSCI construct and the standard plasmid Peft-3::Cas9 expression construct. B. Diagram of GFP tagging of snb-1 using the intron-nested Cbr-unc-119 selectable marker. C.
Erik M. Jorgensen (9870998) +3 more
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Transgenic solutions for the germline [PDF]
WormBook, 2010 One of the most thrilling experiments in biology is to introduce a gene of one’s own design into a favorite animal and examine the effect in the transgenic progeny. Methods to construct, transform and monitor transgenes have been available to worm breeders since the pioneering work of Andy Fire and Craig Mello (Fire, 1986; Mello and Fire, 1995) and the
Merritt, Christopher, Seydoux, Geraldine
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