Results 171 to 180 of about 837,511 (259)

A case report of non‐syndromic colonic ganglioneuroma in a patient with juvenile polyposis

JPGN Reports, EarlyView.
Abstract Colonic ganglioneuromas in children are rare, particularly without associated hereditary syndromes like multiple endocrine neoplasia (MEN2B), neurofibromatosis type 1(NF1), or Phosphatase and tensin homolog hamartoma tumor syndrome (PHTS). We report a 12‐year‐old male with a history of juvenile polyposis syndrome (JPS) and segmental colonic ...
Holly Coffey, Kshitij Arora, Matthew J. Giefer   +2 more
wiley   +1 more source

Olaparib in HR-deficient, metastatic triple-negative breast and platinum-sensitive relapsed ovarian cancers without germline mutations in BRCA1/2: phase 2 EMBRACE trial. [PDF]

Br J Cancer
Sjoquist KM, Dobrovic A, Robledo KP, Nesic K, Baron-Hay S, Ananda S, McCarthy N, Goh J, Steer C, Murray N, Yip S, Mileshkin LR, Fink JL, Chang G, Bailey L, Lee Y, Zebic DS, Kariyawasam UGIU, Shield-Artin K, Jarratt A, Bedő J, Papenfuss AT, Kondrashova O, Wakefield MJ, Vandenberg CJ, Stockler MR, Scott CL, Waring PM.   +27 more
europepmc   +1 more source

When genetics disrupt the gut: Dysmotility and ganglioneuromatosis in multiple endocrine neoplasia type 2B syndrome

JPGN Reports, EarlyView.
Abstract Multiple Endocrine Neoplasia type 2B (MEN2B) is a rare hereditary cancer syndrome characterized by medullary thyroid carcinoma, mucosal neuromas, and pheochromocytoma. Gastrointestinal involvement is common and often manifests as diffuse intestinal ganglioneuromatosis (IGN), which can impair motility and lead to severe constipation, pseudo ...
Aldo Majluta Yeb, Alexander Nasr, Ajay Kaul   +2 more
wiley   +1 more source

Germline Mutations in DNA Repair Genes in Patients with Pancreatic Neuroendocrine Neoplasms: Diagnostic and Therapeutic Implications. [PDF]

Curr Oncol
Jurecka-Lubieniecka B, Ros-Mazurczyk M, Sygula A, Cortez AJ, Krzempek M, Tuleja AB, Kotecka-Blicharz A, Cieslicka M, Oczko-Wojciechowska M, Handkiewicz-Junak D.   +9 more
europepmc   +1 more source

Hepatic Adenomas in Men: Diagnostic Considerations and Management in the Modern Era

Journal of Surgical Oncology, EarlyView.
ABSTRACT Hepatic adenomas (HAs) are rare benign liver tumors traditionally associated with young women, yet contemporary epidemiologic trends reveal increasing recognition among men. Historically, universal resection in males has been recommended because of a nearly tenfold increased risk of malignant transformation as reported by Farges et al.
Teresa Belledent, Julie Nwosu, Kiers Brevik, Raegen M. Abbey, Timothy Pawlik, Dae Sun Hwang, Terry L. Hayes, Ikenna Nwosu, Mohammed O. Suraju, Hassan Aziz   +9 more
wiley   +1 more source

Prevalence and clinical relavance of germline mutations in Chinese patients with pancreatic cancer. [PDF]

Cell Commun Signal
Jiang Y, Li D, Liu Y, Qin J, Chen H, Zhang J, Gu Y, Shen B, Jin J.   +8 more
europepmc   +1 more source

Concentration‐Based Short‐Course Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) at Interval Cytoreductive Surgery (iCRS) for Advanced Ovarian Cancer: Final Analysis of Overall Survival in a Phase 2 Trial

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background The optimal regimen for Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) remains controversial. We aim to present long‐term overall survival results from our phase 2 trial evaluating a concentration‐based short‐course regimen for ovarian cancer at the time of interval CytoReductive Surgery (iCRS).
Thales Paulo Batista, Ana Beatriz Diniz de Barros, Vandré Cabral Gomes Carneiro, Rodrigo Tancredi, Levon Badiglian‐Filho, Ronaldo Lúcio Rangel Costa, André Lopes, Bruno José de Queiroz Sarmento, Cristiano Souza Leão   +8 more
wiley   +1 more source

Prevalence of <i>BRCA1</i> and <i>BRCA2</i> Germline Mutations in Vietnamese Patients With Triple-Negative Breast Cancer. [PDF]

Cancer Control
Toan TT, To TV, Lan TTH, Thinh NV, Anh DTN, Hanh BTM.   +5 more
europepmc   +1 more source

Germline mutations in PPP2R1B in patients with a personal and family history of cancer. [PDF]

JCI Insight
Mazhar S, O'Connor CM, Harold A, Dowdican AC, Ulintz PJ, Hanson EN, Zhang Y, Jacobs MF, Merajver SD, Jackson MW, Scott A, Sieuwerts AM, Chinnaiyan AM, Narla G.   +13 more
europepmc   +1 more source

WDR72 Drives Esophageal Squamous Cell Carcinoma Progression by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a high rate of recurrence and metastasis, necessitating the identification of novel therapeutic targets. WD repeat‐containing protein 72 (WDR72) has been linked to various cancers, but its specific biological function and underlying mechanism in ESCC remain largely ...
Hao Wu, Zhong‐Xiang Jiang, Zheng Jiang
wiley   +1 more source