Results 151 to 160 of about 837,511 (259)

Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations. [PDF]

Endocr Relat Cancer
Lim ES, Bayley JP, Gimenez-Roqueplo AP, Clifton-Bligh RJ, Richter S.   +4 more
europepmc   +1 more source

Is Ductal Carcinoma In Situ a Precursor or Low‐Risk Variant of Invasive Breast Cancer? A Population Perspective

International Journal of Cancer, EarlyView.
ABSTRACT Ductal carcinoma in situ (DCIS) is usually detected with mammography screening and assumed to be a precursor of invasive ductal cancer (IDC) of the breast. Yet, despite an approximately 10‐fold increase in the rate of DCIS detection and treatment within 20 years following implementation of mammography screening in the United States, IDC ...
Ismail Jatoi, Adalberto M. Filho, Gretchen Gierach, Hyuna Sung, Philip S. Rosenberg   +4 more
wiley   +1 more source

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid. [PDF]

Sci Adv
de la Calle Arregui C, Frank AR, Mun K, Kim J, Majmudar K, Bishop JA, Lewis C, Xie Y, McFadden DG.   +8 more
europepmc   +1 more source

Occult serous tubal intraepithelial carcinoma and high‐grade serous carcinoma at risk‐reducing salpingo‐oophorectomy in BRCA1/2 carriers: A Czech two‐center cohort

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Risk‐reducing salpingo‐oophorectomy is the standard intervention for prevention of tubo‐ovarian carcinoma in women with pathogenic BRCA1/2 variants, yet the optimal timing remains clinically challenging, particularly for BRCA2 carriers.
Olga Zikan Dubova, Lukas Dostalek, Michal Emingr, Munachiso Ndukwe, Michal Zikan   +4 more
wiley   +1 more source

Efficacy of olaparib in advanced cancers with somatic or germline mutations in BAP1, BARD1, BRIP1 and PALB2. [PDF]

ESMO Open
Joris S, Denys H, Collignon J, Rasschaert M, de Roodenbeke DT, Duhoux FP, Canon JL, Tejpar S, Mebis J, Decoster L, Aftimos P, De Grève J.   +11 more
europepmc   +1 more source

Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Lynch syndrome and BRCA‐mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer ...
Anna Weimer, Nadeem Abu‐Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y. S. Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting‐Chang Chang, Munanchiso Ndukwe Iheme Jr, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B. Olawaiye   +20 more
wiley   +1 more source

Prevalence of BRCA1 and BRCA2 Germline Mutations in Western Saudi Patients with Epithelial Tubo-Ovarian Carcinoma. [PDF]

Saudi Med J
Mehros W, Aldaheri F, Alqarni A, Aljehani S, Alnamlah A, Althubaiti A, Huneef S, Jifree H.   +7 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

The dual impact of GBA1 in disease: from germline mutations in neurological disorders to alterations in cancer. [PDF]

Cell Death Discov
Fantini V, Di Rauso G, Fioravanti V, Ciarrocchi A, Cavallieri F, Sancisi V.   +5 more
europepmc   +1 more source

Adverse Effects of Unsaturated Organic Compounds on Kinetic States During Locomotion Uncovered by Comprehensive Analysis of Behavioral Toxicities in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT Organisms in human living spaces are surrounded by a variety of engineered substances. These chemical compounds have unexpected effects on the environment and human health. In particular, workers in industries face the risk of a health hazard caused by high‐dose or long‐term exposure to chemicals in the workplace.
Masahiro Tomioka
wiley   +1 more source