Results 141 to 150 of about 279,197 (333)
MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
Advanced Science, EarlyView.This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang +18 more
wiley +1 more source
Advanced Science, EarlyView.Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye +12 more
wiley +1 more source
Factors Affecting Nursing Students\u27 Attitudes Towards Older Adults [PDF]
, 2006 The purpose of this study was to measure nursing students\u27 attitudes towards older adults and to determine, if possible, factors which affect nursing students\u27 attitudes toward older adults.
McCammon, Tracy
core +1 more source
Advanced Science, EarlyView.Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao +13 more
wiley +1 more source
On the Edge: Facing a Challenging and Uncertain Future [PDF]
, 2006 Introduces the Boston Elder Economic Security Standard as a tool to assess the real economic circumstances, needs, and resources of the low- and middle-income elderly in Boston, depending on their health, housing, marital status and other ...
Ellen A. Bruce +2 more
core
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, EarlyView.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
The Effects of Loneliness and Social Isolation on Older Individuals: A Case Study
SenectusThis study carries out a gerontological evaluation to address the issue of the care needs that emerge with the aging process and the growing population of older individuals.
Faruk Yaşar Gürdal
doaj +1 more source