Results 71 to 80 of about 5,004,763 (240)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde   +4 more
wiley   +1 more source

Current management of gestational trophoblastic disease

open access: yes, 2015
© 2014 Elsevier Ltd. Gestational trophoblastic disease is a rare pregnancy-related disorder. It comprises of partial mole, complete mole, choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour. Novel immunohistochemical
Ngan, Hextan Y.S.   +3 more
core   +1 more source

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥ 20 weeks to a tertiary fetal medicine unit (2020–2025).
Hadas Miremberg   +11 more
wiley   +1 more source

Reproductive patterns and the risk of gestational trophoblastic disease

open access: yes, 1985
The relation between reproductive pattern and the risk of gestational trophoblastic disease was evaluated in a case-control study conducted in Northern Italy on 310 women with histologically confirmed gestational trophoblastic disease and two control ...
F. Parazzini   +3 more
core   +1 more source

Non‐Invasive Prenatal Diagnosis of Haemoglobinopathies: From Concept to Clinical Reality

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Haemoglobinopathies are the most prevalent monogenic disorders worldwide, contributing significantly to childhood morbidity and mortality. Preventive strategies, including carrier screening and prenatal diagnosis, have successfully reduced disease incidence in regions with established programmes.
Irene Leonidou   +7 more
wiley   +1 more source

Actual problem UDC:612.818:616-006:615-085 Archive of Oncology 2002;10(2):71-5.

open access: yes, 2014
Gestational trophoblastic disease belongs to a spectrum of rare tumors originating from trophoblast. It spreads from the benignant disease- uncomplicated partial mole to the most malignant choriocarcinoma in stage IV of disease with brain metastases ...
Tamara Vujkov   +2 more
core  

Leptomeningeal spread of gestational trophoblastic neoplasia in a 19-year old woman

open access: yesGynecologic Oncology Reports, 2019
Gestational trophoblastic neoplasia (GTN) with brain metastasis is usually seen in patients with advanced disease. Ten percent of metastatic gestational trophoblastic disease involves the brain and spinal cord, most often manifesting as an intracerebral ...
Nnamdi I. Gwacham   +3 more
doaj   +1 more source

A review on management of gestational trophoblastic neoplasia

open access: yesJournal of Family Medicine and Primary Care, 2020
Background: The rare presence of malignant cancerous cells afar any type of pregnancy is known as gestational trophoblastic neoplasia (GTN). GTN are benign lesions which mostly happen due to the activity of extravillous trophoblast cells and the ...
Seyedeh Reyhaneh Yousefi Sharami   +1 more
doaj   +1 more source

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Ying‐Ying Xue   +7 more
wiley   +1 more source

Management of symptomatic uterine arteriovenous malformations after gestational trophoblastic disease: The Brazilian experience and possible role for depot medroxyprogesterone acetate and tranexamic acid treatment

open access: yes, 2018
OBJECTIVE: To identify predictive variables of heavy vaginal bleeding from uterine arteriovenous malformation (uAVM) after gestational trophoblastic disease (GTD) and review outcomes with different treatment strategies.
Parente, Raphael Câmara Medeiros [UNESP]   +14 more
core  

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