Results 71 to 80 of about 7,713 (194)

Invasive mole in a perimenopausal woman with lung and vaginal metastases: A case report

Clinical Case Reports, 2019
Gestational trophoblastic disease can result in serious complications and disease progression. Therefore, follow‐up of such patients is essential for early detection of malignant trophoblastic tumors and to reduce mortality rate.
Cristina Martínez Leocadio, José García Villayzán, Jesús García‐Foncillas López, Franklin Idrovo, Javier Plaza Arranz, Manuel Albi González   +5 more
doaj   +1 more source

MCT1‐mediated bidirectional propionate transport across human placental syncytiotrophoblast layer: insights from a trophoblast stem cell‐derived barrier model

The Journal of Physiology, EarlyView.
Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani, Rin Midorikawa, Akari Kasuya, Saki Noguchi, Kohei Yamamoto, Tomohiro Nishimura, Hirokazu Kaji, Takeshi Hori, Masatoshi Tomi   +8 more
wiley   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

GESTATIONAL TROPHOBLASTIC DISEASE

Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya, 2021
Gestational trophoblastic disease (GTD) is a group of tumors defined by abnormal trophoblastic proliferation. GTD is divided into hydatidiform moles (contain villi) and other trophoblastic neoplasms (lack villi).1 The malignant forms of the disease are also collectively known as gestational trophoblastic tumors or neoplasia (GTN).GTN includes the ...
openaire   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Vaginal epithelioid trophoblastic tumor mimicking vaginal fistula: a case report and literature review

Frontiers in Oncology
BackgroundEpithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia. This article presents a case of vaginal ETT, initially misdiagnosed as vaginal carcinoma, in a patient with no history of gestational trophoblastic ...
Dong-mei Li, Dong-mei Li, Xiu-zhang Yu, Xiu-zhang Yu, Ming-rong Qie, Ming-rong Qie, Rui-qi Duan, Rui-qi Duan   +7 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source