Results 91 to 100 of about 505,040 (313)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Temporal relationships between speech and hand gestures in the vicinity of potential turn boundaries in German and Swedish conversation

Language and Cognition
Both gesture and talk are basic building blocks of face-to-face conversation. In this study, we address the temporal dynamics of hand gesture phases relative to places and types of turn transition.
Margaret Zellers, Jan Gorisch, David House   +2 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Design of Human–Computer Interaction Gesture Tracking Model Based on Improved PSO and KCF Algorithms

IEEE Access
The detection and tracking of gesture targets is an important aspect in the dynamic gesture recognition. To meet the accuracy and speed requirements of human-computer interaction for dynamic gesture recognition, this study explores long-term gesture ...
Dinghua He, Yan Yang, Rangzhong Wu
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Intelligent Contactless Gesture Recognition Using WLAN Physical Layer Information

IEEE Access, 2019
Contactless gesture recognition is an emerging interactive technique in ubiquitous and mobile computing. It combines the linguistics with the wireless signals to analyze, judge, and integrate human gestures by the usage of intelligent algorithms.
Shujie Ren, Huaibin Wang, Liangyi Gong, Chaocan Xiang, Xuangou Wu, Yufeng Du   +5 more
doaj   +1 more source

Structuring information through gesture and intonation [PDF]

, 2005
Face-to-face communication is multimodal. In unscripted spoken discourse we can observe the interaction of several “semiotic layers”, modalities of information such as syntax, discourse structure, gesture, and intonation.
Jannedy, Stefanie, Mendoza-Denton, Norma
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

iMiGUE: An Identity-free Video Dataset for Micro-Gesture Understanding and Emotion Analysis [PDF]

, 2021
Xin Liu, Henglin Shi, Haoyu Chen, Zitong Yu, Xiaobai Li, Guoying Zhaoz   +5 more
openalex   +1 more source