Results 101 to 110 of about 127,357 (301)

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Neuron-like staining by different GFAP antibodies.

, 2013
Neuron-like structures are stained by the GFAP+1 (A), GFAP C-terminal (B) and GFAP N-terminal (C) antibody (arrows). The C-terminal and N-terminal antibodies also stain astrocytes (B–C, arrowheads).
Dave Speijer (369493), Simone A. van den Berge (369492), Jinte Middeldorp (110012), Elly M. Hol (82147), Eleonora Aronica (135729)   +4 more
core   +1 more source

THE INFLUENCE OF SAMPLING TIME TO SERUM GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS IN ACUTE STROKE

Malang Neurology Journal, 2019
Background: Serum Glial Fibrillary Acidic Protein (GFAP) is a great potential for biomarker that is widely studied as a diagnostic biomarker of acute stroke.
Neila Raisa, Hidayat Sujuti, Masruroh Rahayu, Mochamad Dalhar   +3 more
doaj   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Glial Fibrillary Acidic Protein (GFAP): Neuroinflammation Biomarker in Acute Ischemic Stroke

Journal of Inflammation Research, 2021
Lisda Amalia Department of Neurology, The First Affiliated Hospital of Faculty of Medicine, Universitas Padjadjaran/RSUP dr. Hasan Sadikin, Bandung, IndonesiaCorrespondence: Lisda Amalia Jl.Pasteur 38, Bandung, 40161, IndonesiaEmail dr.lisda@gmail ...
Amalia L
doaj  

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

p62 in Gfap^+/R236H mice colocalizes with Gfap aggregates and is reduced with loss of Nrf2.

, 2013
(A) p62 immunohistochemistry in hippocampus from Gfap+/R236H/Nrf2+/+ mice shows astrocytic cells that are not apparent in Gfap+/+ mice. Gfap+/R236H/Nrf2−/− mice show similarly stained cells (3 mos of age).
Emily M. Jobe (102132), Albee Messing (320554), Tracy L. Hagemann (320553)   +2 more
core   +1 more source

Magnetic Resonance Imaging Characteristics of Autoimmune Glial Fibrillary Acidic Protein (GFAP) Astrocytopathy: A Pediatric Series in Southwest China

Neuropsychiatric Disease and Treatment, 2023
Weiqin Cheng,1 Ling He,1 Hechuan Luo,1 Yan Jiang,2 Chengbing Tan,2 Xiao Fan1 1Department of Radiology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key ...
Cheng W, He L, Luo H, Jiang Y, Tan C, Fan X   +5 more
doaj  

Cutaneous nodular fasciitis in the dog. Morphological and immunohistochemical study

Brazilian Journal of Veterinary Pathology, 2009
Nodular fasciitis is a benign soft tissue lesion commonly diagnosed in human beings, but with rare description in dogs and cats. A female, spayed, 7.5 years old, otherwise healthy Labrador was examined because of a nodular growth of rapid development in ...
Lissandro G. Conceição, Livia M. R. Acha, Jose C. L. Moreira, Fabricia H. Loures, Lucia M. R. Silveira, Renee L. Amorim, Rafael T. Neto   +6 more
doaj   +1 more source