Results 31 to 40 of about 102,624 (263)
Patologìâ, 2023 Aim. Immunohistochemical study of rat hippocampal neurons and astrocytes at different time-points of experimental brain hemorrhage treated with acelysin and nimotop. Materials and methods. Subarachnoid hemorrhage (SAH) was modeled according to R.
O. Yu. Polkovnikov, S. I. Tertyshnyi
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The role of GFAP and vimentin in learning and memory [PDF]
Biological Chemistry, 2019 Abstract Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive ...
Wilhelmsson, Ulrika +6 more
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Enteric Glia: S100, GFAP, and Beyond [PDF]
The Anatomical Record, 2019 ABSTRACTSince several years, the enteric nervous system (ENS) is getting more and more in the focus of gastrointestinal research. While the main interest was credited for years to the enteric neurons and their functional properties, less attention has been paid on the enteric glial cells (EGCs). Although the similarity of EGCs to central nervous system
David Grundmann +6 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
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GFAP and its role in Alexander disease [PDF]
Experimental Cell Research, 2007 Here we review how GFAP mutations cause Alexander disease. The current data suggest that a combination of events cause the disease. These include: (i) the accumulation of GFAP and the formation of characteristic aggregates, called Rosenthal fibers, (ii) the sequestration of the protein chaperones alpha B-crystallin and HSP27 into Rosenthal fibers, and (
Roy A, Quinlan +3 more
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
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Changes in the density of astrocytes in the brain of rats caused by a single prolonged stress [PDF]
Medicinski PodmladakIntroduction: Post-traumatic stress disorder (PTSD) is a chronic syndrome caused by a traumatic stressful event. Numerous patients do not respond to conventional therapy, which shows that the pathogenetic mechanisms of PTSD are insufficiently known.
Ivaz Sava +2 more
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Klinik Psikiyatri Dergisi, 2023 INTRODUCTION: The neurodevelopmental hypothesis of schizophrenia suggests that alterations of glial fibrillary acidic protein (GFAP) and glial cell line-derived neurotrophic factor (GDNF) functions may play a role in the pathogenesis of schizophrenia ...
İhsan Çetin +4 more
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