Results 151 to 160 of about 194,651 (386)

Integration of proteomics and bioinformatics in traumatic brain injury biomarker discovery

BioTechnologia
Background Traumatic brain injury (TBI) is a significant medical crisis with no FDA-approved therapies to improve functional outcomes. Key biomarkers, such as glial fibrillary acidic protein (GFAP), S-100 calcium-binding protein B (S-100B), and ubiquitin
Mohamed M. Mohamed, El-Sayed A. El-Absawy, Hala M. Ahmed, Mohamed E. Hasan   +3 more
doaj   +1 more source

Pathology and Astrocytes in Autism

Neuropsychiatric Disease and Treatment, 2023
Gelareh Vakilzadeh,1,2 Veronica Martinez-Cerdeño1– 3 1Department of Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA, USA; 2Institute for Pediatric Regenerative Medicine, and Shriners Hospitals for Children, Sacramento, CA ...
Vakilzadeh G, Martinez-Cerdeño V
doaj  

Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function

Frontiers in Neuroscience, 2019
Chronic microglial activation is a prominent feature of many chronic neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. To investigate the effects of chronic microglial activation on cerebellar structure and motor function ...
E. Gyengesi, A. Rangel, F. Ullah, Huazheng Liang, Garry Niedermayer, Rustam Asgarov, Madhuri Venigalla, D. Gunawardena, T. Karl, G. Münch   +9 more
semanticscholar   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

eLife, 2019
Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes.
Rachel A. Battaglia, Adriana S. Beltran, Samed Delic, R. Dumitru, Jasmine Robinson, P. Kabiraj, Laura E. Herring, V. Madden, Namritha Ravinder, E. Willems, R. A. Newman, R. Quinlan, J. Goldman, M. Perng, M. Inagaki, Natasha T. Snider   +15 more
semanticscholar   +1 more source

Diaphragm Neurostimulation Reduces Percentages of Hippocampal Reactive Astrocytes and GFAP Serum Concentrations in Pigs Mechanically Ventilated for 50 Hours [PDF]

, 2021
Thiago Bassi, K. Fernández, Elizabeth Rohrs, Marlena Ornowska, Michelle Nicholas, M. Gani, D. Evans, S.C. Reynolds   +7 more
openalex   +1 more source

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Olig2-Lineage Astrocytes: A Distinct Subtype of Astrocytes That Differs from GFAP Astrocytes

Frontiers in Neuroanatomy, 2018
Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are known to constitute heterogeneous populations that differ in their morphology, gene expression and function.
K. Tatsumi, A. Isonishi, Miwako Yamasaki, Yoshie Kawabe, Shoko Morita-Takemura, Kazuki Nakahara, Yuki Terada, Takeaki Shinjo, H. Okuda, Tatsuhide Tanaka, A. Wanaka   +10 more
semanticscholar   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Caspase Cleavage of GFAP Produces an Assembly-Compromised Proteolytic Fragment that Promotes Filament Aggregation

ASN Neuro, 2013
IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation.
Mei-Hsuan Chen, Tracy L. Hagemann, Roy A. Quinlan, Albee Messing, Ming-Der Perng   +4 more
doaj   +1 more source