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Methods, 1996
The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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Expression Specificity of GFAP Transgenes
Neurochemical Research, 2004Glial fibrillary acidic protein (GFAP) is an intermediate filament protein found predominantly in astrocytes. This specificity has recommended the GFAP gene promoter for targeting transgene expression to astrocytes. Although both we [Brenner et al. J. Neurosci. 14:1030-1037, (1994)] and others [Mucke et al. New Biol.
Mu, Su +5 more
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Clinical characteristics of autoimmune GFAP astrocytopathy
Journal of Neuroimmunology, 2019The clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy remain to be elucidated. We describe here the clinical features of 14 patients with GFAP astrocytopathy confirmed by detection of GFAP-IgG in cerebrospinal fluid (CSF). The novel findings of this study are as follows.
Akio Kimura +2 more
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GFAP mutations in Alexander disease
International Journal of Developmental Neuroscience, 2002AbstractAlexander disease is a rare but often fatal disease of the central nervous system. Infantile, juvenile and adult forms have been described that present with different clinical signs, but are unified by the characteristic presence in astrocytes of Rosenthal fibers–protein aggregates that contain glial fibrillary acidic protein (GFAP) and small ...
Rong, Li +3 more
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Neuropathological validation of plasma GFAP
Alzheimer's & Dementia, 2022AbstractBackgroundGlial fibrillary acidic protein (GFAP) is an astrocytic marker that has been recently associated with fluid and imaging biomarkers of amyloid and tau pathologies in the Alzheimer’s disease (AD) spectrum. Plasma GFAP has also shown to be a strong indicator of early brain amyloidosis in preclinical AD.
Andréa Lessa Benedet +9 more
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Neurology, 2010
Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
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Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
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GFAP-Immunoreactivity following hypothermic forebrain ischemia
Metabolic Brain Disease, 1997This study investigated the effect of intra-ischemic hypothermia on astroglial reactions in the hippocampus following cerebral ischemia. Mongolian gerbils were subjected to forebrain ischemia by bilateral carotid occlusion of 10 min at a) 30 degrees C and b) 37 degrees C followed by normothermic reperfusion ranging from 1 to 3 days (d).
K, Kumar, X, Wu, A T, Evans
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1999
Abstract GFAP, glial fibrilfary acidic protein, is a member of the intermediate filament protein superfamily. It is expressed almost exclusively in astrocytes of the CNS but is also found in some cells of the PNS such as non-myelinating Schwann cells. GFAP is extensively used in histology and pathology as a cell-type marker.
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Abstract GFAP, glial fibrilfary acidic protein, is a member of the intermediate filament protein superfamily. It is expressed almost exclusively in astrocytes of the CNS but is also found in some cells of the PNS such as non-myelinating Schwann cells. GFAP is extensively used in histology and pathology as a cell-type marker.
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Acta Neurologica Scandinavica, 2009
A solid-phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP-specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was absorbed onto polystyrene beads, followed by incubation in dilutions of serum.
J, Ruutiainen +4 more
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A solid-phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP-specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was absorbed onto polystyrene beads, followed by incubation in dilutions of serum.
J, Ruutiainen +4 more
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