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Journal of Neuroimmunology, 2021
Glial fibrillary acidic protein (GFAP) is the main constituent of the astrocytic cytoskeleton, overexpressed during reactive astrogliosis-a hallmark of Alzheimer's Disease (AD).
G. Katsipis +3 more
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Glial fibrillary acidic protein (GFAP) is the main constituent of the astrocytic cytoskeleton, overexpressed during reactive astrogliosis-a hallmark of Alzheimer's Disease (AD).
G. Katsipis +3 more
semanticscholar +1 more source
Methods, 1996
The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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Role of GFAP in CNS injuries [PDF]
Neuroscience Letters, 2014 The role of GFAP in CNS injury is reviewed as revealed by studies using GFAP null mice. In order to provide background information for these studies, the effects of absence of GFAP in the uninjured astrocyte are also described. Activities attributable to GFAP include suppressing neuronal proliferation and neurite extension in the mature brain, forming ...
exaly +3 more sources
Progress in Neurobiology, 2011
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery
Middeldorp, J., Hol, E.M.
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Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery
Middeldorp, J., Hol, E.M.
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Expression Specificity of GFAP Transgenes
Neurochemical Research, 2004Glial fibrillary acidic protein (GFAP) is an intermediate filament protein found predominantly in astrocytes. This specificity has recommended the GFAP gene promoter for targeting transgene expression to astrocytes. Although both we [Brenner et al. J. Neurosci. 14:1030-1037, (1994)] and others [Mucke et al. New Biol.
Mu, Su +5 more
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Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD
Neurology, 2019Objective To test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are an intermediate astrocyte and neuron filaments, respectively, are clinically useful biomarkers of disease activity
Mitsuru Watanabe +10 more
semanticscholar +1 more source
GFAP mutations in Alexander disease
International Journal of Developmental Neuroscience, 2002AbstractAlexander disease is a rare but often fatal disease of the central nervous system. Infantile, juvenile and adult forms have been described that present with different clinical signs, but are unified by the characteristic presence in astrocytes of Rosenthal fibers–protein aggregates that contain glial fibrillary acidic protein (GFAP) and small ...
Rong, Li +3 more
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Neuropathological validation of plasma GFAP
Alzheimer's & Dementia, 2022AbstractBackgroundGlial fibrillary acidic protein (GFAP) is an astrocytic marker that has been recently associated with fluid and imaging biomarkers of amyloid and tau pathologies in the Alzheimer’s disease (AD) spectrum. Plasma GFAP has also shown to be a strong indicator of early brain amyloidosis in preclinical AD.
Andréa Lessa Benedet +9 more
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Neurology, 2010
Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
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Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
openaire +1 more source
GFAP-Immunoreactivity following hypothermic forebrain ischemia
Metabolic Brain Disease, 1997This study investigated the effect of intra-ischemic hypothermia on astroglial reactions in the hippocampus following cerebral ischemia. Mongolian gerbils were subjected to forebrain ischemia by bilateral carotid occlusion of 10 min at a) 30 degrees C and b) 37 degrees C followed by normothermic reperfusion ranging from 1 to 3 days (d).
K, Kumar, X, Wu, A T, Evans
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