Results 141 to 150 of about 127,357 (301)
VGB treatment decreased the number of GFAP positive cells in hippocampus of Tsc1GFAPCKO mice.
, 2013 (A) Vehicle-treated Tsc1GFAPCKO mice (KO + Veh) displayed a diffuse increase in GFAP-positive cells in neocortex and hippocampus compared with the vehicle-treated control mice (Cont + Veh). VGB treatment partially prevented this increase in GFAP-positive
Michael Wong (204064) +3 more
core +1 more source
PatologìâAim. To describe the morphological features of GFAP-positive cells in the basal magnocellular nucleus (BMN) of the rat brain of experimental rats under conditions of early pathogenetically substantiated correction of colchicine-induced neurodegeneration ...
M. V. Danukalo , Yu. M. Kolesnyk
doaj +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Advanced Science, EarlyView.PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang +5 more
wiley +1 more source
, 2012 quantification of GFAP by Western Blot from homogenates of whole hippocampus. Each column represents the levels of GFAP expressed as a ratio of β-actin expression run in the same gel (mean ± SEM; Adult, n = 8; aged, n = 5; aCSF, n = 6; LPS-treated, n = 6)
Polina Petkova-Kirova (135984) +7 more
core +1 more source
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
Expression of Acidic Fibrillar Protein and Neuroglobin in Thrombolytic Patients in Ischemic Stroke
Clinical Interventions in AgingHanna Pawluk,1 Renata Kołodziejska,1 Grzegorz Grześk,2 Mariusz Kozakiewicz,3 Agnieszka Kosinska,4 Mateusz Pawluk,1 Elżbieta Grzechowiak,5 Jakub Wojtasik,6 Grzegorz Kozera7 1Department of Medical Biology and Biochemistry, Faculty of ...
Pawluk H +8 more
doaj
Фармакоэкономика, 2015 becoming increasingly widespread evaluation of the blood-brain barrier (BBB) resistance to predict severity and outcome of epilepsy, stroke, traumatic brain injury (TBI) and other neurological disorders by assessment of neuron-specific proteins (NSP ...
D. V. Blinov
doaj
Advanced Science, EarlyView.A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong +17 more
wiley +1 more source