Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers +12 more
wiley +1 more source
Role of Ghrelin in the Pathophysiology of Gastrointestinal Disease
Ghrelin is a 28-amino-acid peptide that plays multiple roles in humans and other mammals. The functions of ghrelin include food intake regulation, gastrointestinal (GI) motility, and acid secretion by the GI tract.
doaj +1 more source
Abstract This study examined the effects of different food deprivation periods (0, 7, 14, 28, 42, and 84 days) on physical indexes, appetite gene expression, physiological and biochemical levels and intestinal histology in Japanese eel (Anguilla japonica).
Xiangbiao Zeng +8 more
wiley +1 more source
Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome [PDF]
Marisa Ferreira‐Marques +14 more
openalex +1 more source
Lifestyle implications of the paradox and management of oxidative stress in sperm
Abstract figure legend Lifestyle factors influencing male fertility. Schematic overview of lifestyle factors with beneficial (left) and detrimental (right) effects on male fertility. A balanced diet, regular moderate physical activity and stress management strategies support sperm function and redox homeostasis.
Giuseppe T. Patané +6 more
wiley +1 more source
Ghrelin modulates testicular damage in a cryptorchid mouse model
Enrica Bianchi +4 more
openalex +2 more sources
The ghrelin agonist,
Pu‐Qing Yuan +3 more
openalex +1 more source
Learning Hunger: Conditioned Anticipatory Ghrelin Responses in Energy Homeostasis [PDF]
Karen L. Teff
openalex +1 more source
Elevated Umbilical Cord Ghrelin Concentrations in Small for Gestational Age Neonates [PDF]
Juliet Farquhar +5 more
openalex +1 more source
Association between CLOCK 3111 T/C polymorphism with ghrelin, GLP-1, food timing, sleep and chronotype in overweight and obese Iranian adults [PDF]
Sara Rahati +4 more
openalex +1 more source

