Results 91 to 100 of about 8,222 (228)
Allosteric modulation of ghrelin receptor signaling by lipids
Nature Communications, 2021 The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects ...
Marjorie Damian +11 more
doaj +1 more source
Mutations in the ghrelin receptor gene GHSR in congenital hypopituitarism
Problems of Endocrinology, 2017 The results of molecular genetic studies indicate the potential involvement of ghrelin in the pathogenesis of some dwarfism forms. However, in the case of isolated somatotropin insufficiency, mutations in the ghrelin receptor gene are a rare cause of the disease.
Elena B. Bashnina +6 more
openaire +2 more sources
Molecular MetabolismObjective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim +13 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2010 The results of presented study demonstrate expression of ghrelin, its functional receptor GHSR-1a and their genes in spermatogenic cells of rat testis suggesting their functioning within seminiferous epithelium.
Marcin Ruciński +7 more
doaj +1 more source
A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Advanced Science, 2023 Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood.
Tingting Yi +21 more
doaj +1 more source
Relationship between abnormal symptoms of Prader-Willi syndrome model --Snord116 deletion mice and Ghrelin signaling pathway [PDF]
, 2016 Prader–Willi综合症是以进食异常和血液Ghrelin异常升高为特征的遗传肥胖症。其病因是Snord116SnoRNA群的表达缺失。我们构建的Snord116del小鼠模型表现出贪食和血液Ghrelin升高等PWS症状。此次研究中，我们繁育野生型（WT）、Snord116del（SW）、Ghrl-/-（WG）、Ghsr-/-（WR）小鼠，并制备[Snord116del，Ghrl-/-]（SG）和[Snord116del，Ghsr-/-]（SR）双敲除小鼠，对其生长发育 ...
甘利芬
core
Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts. [PDF]
, 2015 Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis,
Casati, L +5 more
core +4 more sources
Analysis of Population Structure and Selection Signatures in Two Iraqi Fat‐Tailed Sheep Breeds
Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.Awassi sheep exhibit clear genetic separation, whereas Hamdani sheep show an admixed profile, with iHS, ROH and Tajima's D analyses identifying breed‐specific candidate genes. Enrichment in immune response, hormone regulation and cellular signalling pathways highlights adaptive evolution and guides future breeding and conservation.
Mervan Bayraktar +6 more
wiley +1 more source
Chloride Balance in Preterm Infants during the First Week of Life
International Journal of Pediatrics, 2012 Objective. To describe the chloride balance in infants born 25–32-week gestation, analyze the association of chloride changes with hydroelectrolytic status and their relationship with perinatal conditions, morbidities, and neurological outcome.
Silvia Iacobelli +4 more
doaj +1 more source
The Journal of Physiology, Volume 603, Issue 17, Page 4817-4843, September 1, 2025.Abstract figure legend Here we construct an anatomical map of brainstem projections to the ventral tegmental area (VTA) and investigate the neurochemical and neurophysiological nature of these VTA‐projecting nucleus of the solitary tract (NTS) neurons.
Caitlin R. Ritchey +2 more
wiley +1 more source