Results 161 to 170 of about 3,121 (172)

Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens

Molecular Biology Reports, 2014
The ghrelin (GHRL), ghrelin receptor (GHSR), and insulin-like growth factor 1 receptor (IGF1R) genes have crucial effects on body weight (BW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR) in many species. However, few studies on associations of GHRL, GHSR, and IGF1R with BWG, FI, and FCR have been reported in chickens.
Sihua Jin, Guiyun Xu, Ning Yang, H. Li, Sirui Chen, Yue Lu   +5 more
openaire   +3 more sources

Identification of a Putative β‐Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR)

ChemMedChem, 2021
AbstractGhrelin is a pleiotropic feeding hormone which also has a pivotal role in the central nervous system. Upon the activation of its receptor, growth hormone secretagogue receptor (GHSR), the Gαq/11‐mediated and the β‐arrestin‐mediated signaling pathways are activated. As the β‐arrestin pathway is a potential drug target, there is a strong need for
Fumika Karaki, Tomoya Oki, Yuma Sakao, Noriko Sato, Shigeto Hirayama, Kanako Miyano, Yasuhito Uezono, Hideaki Fujii   +7 more
openaire   +3 more sources

Diagnostic values of GHSR DNA methylation pattern in breast cancer

Breast Cancer Research and Treatment, 2012
DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis.
Ali Aghajani, Azin Jahangiri Babadi, Ozgur Sahin, Hossein Najmabadi, Pouria Jandaghi, Pouria Jandaghi, Mahdi Malekpour, Mahdi Malekpour, Abbas Mohajeri, Fatemeh Malekpour, Ramesh Omranipour, Irina S. Bondar, Evgeny A. Moskalev, Mahdi Fallah, Vladimir V. Bubnov, Amin Moghaddas Gholami, Jörg D. Hoheisel, Sandeep Kumar Botla, Yasser Riazalhosseini, Yasser Riazalhosseini   +19 more
openaire   +3 more sources

Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle

Molecular Biology Reports, 2009
GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle.
Bao Zhang, Liangzhi Zhang, Miao Zhao, Hong Chen, Chuanying Pan, Yikun Guo, Juqiang Wang, Xianyong Lan, Chuzhao Lei, Chunlei Zhang, S. R. Hu   +10 more
openaire   +2 more sources

GHSR DNA hypermethylation is a new epigenetic biomarker for gastric adenocarcinoma and beyond

Journal of Cellular Physiology, 2019
AbstractAberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan‐cancer biomarker, in gastric cancer (GC).
Mohammad Amini, Pouria Jandaghi, Fatemeh Kamali, Mehdi Manoochehri, Mehdi Manoochehri, Jörg D. Hoheisel, Kobra Foroughi, Hemat Aghagolzade Haji, Fatemeh Talebi   +8 more
openaire   +3 more sources

Expression of ghrelin receptor (GHSR-1a) in rat epididymal spermatozoa and the effects of its activation

Reproductive Biology, 2012
In this study we demonstrated the expression of the ghrelin receptor GHSR-1a in rat spermatids and epididymal spermatozoa, as well as some effects of ghrelin on the spermatozoa in vitro. For the demonstration of GHSR-1a the immunocytochemical, immunofluorescence and Western blotting techniques were applied using three different types of antibodies. The
Agnieszka Ziolkowska, Malgorzata Kotwicka, Piotr Sawiński, Andrzej Łukaszyk, Anna Jankowska, Aldona Kasprzak, Marcin Rucinski, Karolina Sterzyńska, Marek Ruchała   +8 more
openaire   +3 more sources

Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity

Bioorganic & Medicinal Chemistry Letters, 2012
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.
Gary Moore, Chrystelle Marie Rasamison, Graham Dawson, James Charles Bell, Stuart Bradley, Jason Bloxham, Phillip Clarke, John Keily, Gillian A. Bottomley, James G. Horswill, Susan Helen Davis, Patrick Eric Hanrahan, Eleanor Curtis   +12 more
openaire   +3 more sources

GHSR signalling in perinatal phases is involved in liver metabolism at puberty

Journal of Endocrinology
Ghrelin has effects that range from the maturation of the central nervous system to the regulation of energy balance. The production of ghrelin increases significantly during the first weeks of life. Studies have addressed the metabolic effects of liver-expressed antimicrobial peptide 2 (LEAP2) in inhibiting the effects evoked by ghrelin, mainly in ...
Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Carlos Henrique Xavier, Emerielle Cristine Vanzela, Antonio Carlos Boschero, Paulo Matafome, Rodrigo Mello Gomes   +6 more
openaire   +2 more sources

Expression of ghrelin receptor, GHSR-1a, and its functional role in the porcine ovarian follicles

Growth Hormone & IGF Research, 2009
Recently, we reported stimulatory effect of ghrelin alone and in combination with growth hormone (GH) on estradiol secretion, aromatase activity in parallel with inhibitory effect on cell apoptosis. The aim of this study was to analyze the expression of the functional ghrelin receptor (GHS-R type 1a) and the effect of GH on GHSR-1a expression in ...
Dawid Szczepankiewicz, Ewa Łucja Gregoraszczuk, Agnieszka Rak   +2 more
openaire   +3 more sources

Mo1764 - Validation of GHSR Methylation as a Biomarker of Colorectal Cancer

Gastroenterology, 2018
Lucia Migliore, Roberto Spisni, Fabio Coppedè, Andrea Stoccoro, Alessandro Lazzarotti, Maria Rosaria Ritacco   +5 more
openaire   +2 more sources