Results 171 to 180 of about 6,435 (196)
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Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity
Bioorganic and Medicinal Chemistry Letters, 2010Piperazine-bisamide analogs were discovered as partial agonists of human growth hormone secretagogue receptor (GHSR) in a high throughput screen. The partial agonists were optimized for potency and converted into antagonists through structure-activity relationship (SAR) studies.
Kang Dai, Julio C Medina, Leping Li
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Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle
Molecular Biology Reports, 2009GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle.
Bao Zhang, Chuzhao Lei, Shenrong Hu
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Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens
Molecular Biology Reports, 2014The ghrelin (GHRL), ghrelin receptor (GHSR), and insulin-like growth factor 1 receptor (IGF1R) genes have crucial effects on body weight (BW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR) in many species. However, few studies on associations of GHRL, GHSR, and IGF1R with BWG, FI, and FCR have been reported in chickens.
Ning Yang, Huifeng Li, Sirui Chen
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Associations of GHSR gene polymorphisms with chicken growth and carcass traits
Molecular Biology Reports, 2009Ghrelin receptor (GHSR), or growth hormone secretagogue receptor, modulates many physiological effects by binding to its ligand and therefore is a candidate gene for chicken production performance. In this study, five polymorphisms (four SNP and a 'GGTACA' indel) of GHSR gene were genotyped in a F(2) full sib chicken population to investigate their ...
Meixia, Fang +4 more
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Diagnostic values of GHSR DNA methylation pattern in breast cancer
Breast Cancer Research and Treatment, 2012DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis.
Sandeep Kumar, Botla +16 more
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GHSR signalling in perinatal phases is involved in liver metabolism at puberty
Journal of EndocrinologyGhrelin has effects that range from the maturation of the central nervous system to the regulation of energy balance. The production of ghrelin increases significantly during the first weeks of life. Studies have addressed the metabolic effects of liver-expressed antimicrobial peptide 2 (LEAP2) in inhibiting the effects evoked by ...
Marcos Divino Ferreira-Junior +6 more
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GHSR DNA hypermethylation is a new epigenetic biomarker for gastric adenocarcinoma and beyond
Journal of Cellular Physiology, 2019AbstractAberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan‐cancer biomarker, in gastric cancer (GC).
Mohammad Amini +7 more
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МЕТИЛЮВАННЯ ГЕНА GHSR ПРИ НЕОПЛАСТИЧНИХ ПРОЦЕСАХ ПОРОЖНИНИ РОТА
Scientific and practical journal "Stomatological Bulletin"Аберрантні патерни метилювання ДНК розглядають як чутливі та специфічні маркери раннього канцерогенезу, здатні вдосконалити діагностику злоякісних пухлин. Одним із перспективних епігенетичних показників є гіперметилювання гена рецептора стимулювального гормону росту (GHSR), яке корелює з інвазивністю та несприятливим прогнозом низки онкопроцесів.З ...
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GHSR: Growth Hormone Secretagogue Receptor
2016Yue Yin, Shiying Liu, Weizhen Zhang
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