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Endocrinology, 2021 The attached file includes supplementary tables and figures, This submission meets the Extended Data Sets and Supplemental Materials requirements that are included in author guidelines for Endocrinology (Print ISSN 0013-7227, Online ISSN 1945-7170 ...
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Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review
Life Sciences, 2022Growth hormone secretagogue receptor type 1A (GHSR-1A) is a functional receptor of orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that regulate incentive value of artificial reward in substance abuse. Interestingly, GHSR-1A has also shown ligand-independent constitutive activity.
Shreyasi Gupta +2 more
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Genomic Location of the Bovine Growth Hormone Secretagogue Receptor (GHSR) Gene and Investigation of Genetic Polymorphism [PDF]
Animal Biotechnology, 2009 peer reviewedThe growth hormone secretagogue receptor (GHSR) is involved in the regulation of energetic homeostasis and GH secretion. In this study, the bovine GHSR gene was mapped to BTA1 between BL26 and BMS4004. Two different bovine GHSR CDS (GHSR1a
Nicolas Gengler +2 more
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The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice
Neuropharmacology, 2019Ghrelin is an orexigenic hormone that also plays an important role in mood disorders. Our previous studies demonstrated that ghrelin administration could protect against depression-like behaviors of chronic unpredictable mild stress (CUMS) in rodents. However, the mechanism related to the effect of ghrelin on CUMS mice has yet to be revealed.
Qiuqin Han, Na Yue, Yan-Qing Wang
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Molecular cloning and analysis of the ghrelin/GHSR system in Xenopus tropicalis
General and Comparative Endocrinology, 2023Ghrelin is a gut-derived peptide with several physiological functions, including feeding, gastrointestinal motility, and hormonal secretion. Recently, a host defense peptide, liver-expressed antimicrobial peptide-2 (LEAP2), was reported as an endogenous antagonist of growth hormone secretagogue receptor (GHS-R).
Reiko, Wada +5 more
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Acta Physiologica, 2007
AbstractAim: To assess if adenosine is a direct growth hormone secretagogue receptor (GHSR) agonist by investigating the mechanism behind adenosine induced calcium release in human embryonic kidney 293s (HEK) cells expressing GHSR.Methods: Calcium mobilization, cyclic adenosine monophosphate (cAMP) and IP3experiments were performed using HEK cells ...
N-O, Hermansson +3 more
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AbstractAim: To assess if adenosine is a direct growth hormone secretagogue receptor (GHSR) agonist by investigating the mechanism behind adenosine induced calcium release in human embryonic kidney 293s (HEK) cells expressing GHSR.Methods: Calcium mobilization, cyclic adenosine monophosphate (cAMP) and IP3experiments were performed using HEK cells ...
N-O, Hermansson +3 more
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The new mechanism of Ghrelin/GHSR-1a on autophagy regulation
Peptides, 2020Autophagy is associated with several diseases. In recent years, accumulating evidence has suggested that ghrelin pathway exerts a protective effect by regulating autophagy. This review aims to assess the potential role and use of ghrelin as a new treatment for obesity, cardiovascular diseases, nonalcoholic fatty liver disease (NFALD), neurodegenerative
Ming-Jie, Yuan, Tao, Wang
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LEAP2 is a more conserved ligand than ghrelin for fish GHSRs
Biochimie, 2022ABSTRACT Recently, liver-expressed antimicrobial peptide 2 (LEAP2) was identified as an endogenous competitive antagonist and an inverse agonist of the ghrelin receptor GHSR. However, its functions in lower vertebrates are not well understood.
Hao-Zheng Li +5 more
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