Results 111 to 120 of about 26,375 (226)

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate. [PDF]

PLoS ONE, 2012
The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear.
Roberto P Stock, Jonathan Brewer, Kerstin Wagner, Blanca Ramos-Cerrillo, Lars Duelund, Kit Drescher Jernshøj, Lars Folke Olsen, Luis A Bagatolli   +7 more
doaj   +1 more source

The Effect of Solutes on the Temperature of Miscibility Transitions in Multi-component Membranes

, 2017
We address questions posed by experiments which show that most small-chain alcohols reduce the miscibility transition temperature when added to giant plasma membrane vesicles, but increase that temperature when added to giant unilamellar vesicles.
Allender, D. W., Schick, M.
core   +1 more source

Study of the Interaction of a Novel Semi-Synthetic Peptide with Model Lipid Membranes

Membranes, 2020
Most linear peptides directly interact with membranes, but the mechanisms of interaction are far from being completely understood. Here, we present an investigation of the membrane interactions of a designed peptide containing a non-natural, synthetic ...
Lucia Sessa, Simona Concilio, Peter Walde, Tom Robinson, Petra S. Dittrich, Amalia Porta, Barbara Panunzi, Ugo Caruso, Stefano Piotto   +8 more
doaj   +1 more source

Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: targetable nanocomplexes for in vivo nucleic acid delivery [PDF]

, 2017
One of the greatest challenges for the development of genetic therapies is the efficient targeted delivery of therapeutic nucleic acids. Towards this goal, we have introduced a new engineering initiative in self-assembly of biologically safe and stable ...
A.D. Tagalakis, A.M. Aldossary, Andersen, Askes, Azmi, Ballarin-Gonzalez, Banda, Beales, Bella, Bhatia, C. Yu-Wai-Man, Cans, Chan, D. McCarthy, Dimova, Du, F. Syed, Gao, Gratton, Hadorn, Hadorn, Hadorn, Hadorn, Hadorn, Hall, Honda, Hood, J. Meng, Kas, Kenny, Kwok, Kwok, L.-P. Wu, Li, Mally, Mannisto, Markiewski, Mauroy, Meng, Moghimi, Moghimi, Moghimi, Monsky, Montes, Munye, Munye, Pardi, Parolini, Pautot, Pautot, R. Maeshima, Romoren, S.L. Hart, S.M. Moghimi, Sandre, Schweiger, Semple, Sheridan, Tagalakis, Tagalakis, Tagalakis, Tagalakis, Tagalakis, Tagalakis, Tagalakis, Tagalakis, Veatch, Weng, Wibroe, Williford, Writer, Xiong, Yin, Yu, Yu-Wai-Man, Zhang, Zhang, Zhou   +77 more
core   +2 more sources

Biomimetic Iridescent Skin: Robust Prototissues Spontaneously Assembled from Photonic Protocells

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Uniform nanoparticles are induced to form arrays (photonic crystals) in the cores of biopolymer capsules, endowing these ‘protocells’ with structural color. These protocells are then assembled into large self‐standing objects, i.e., prototissues, with robust mechanical properties as well as iridescent optical properties.
Medha Rath, Briahnah Streeter, Satyam Srivastava, Jemma Wood, William E. Bentley, Taylor J. Woehl, Srinivasa R. Raghavan   +6 more
wiley   +1 more source

Oxyanion transport across lipid bilayers: direct measurements in large and giant unilamellar vesicles.

Chemical Communications, 2020
A simple di(thioamido)carbazole 1 serves as a potent multispecific transporter for various biologically relevant oxyanions, such as drugs, metabolites and model organic phosphate.
Krzysztof M. Bąk, B. van Kolck, Krystyna Maslowska-Jarzyna, Panagiota Papadopoulou, A. Kros, M. Chmielewski   +5 more
semanticscholar   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Osmotic Gradients Induce Bio-reminiscent Morphological Transformations in Giant Unilamellar Vesicles

Frontiers in Physiology, 2012
We report observations of large-scale, in-plane and out-of-plane membrane deformations in giant uni- and multilamellar vesicles composed of binary and ternary lipid mixtures in the presence of net transvesicular osmotic gradients.
Kamila eOglecka, Jeremy eSanborn, Atul N Parikh, Atul N Parikh, Rachel Susan Kraut   +4 more
doaj   +1 more source