Results 221 to 230 of about 52,294 (289)

Efficient and rapid isolation of native AMPA receptor complexes for cryo‐EM

open access: yesProtein Science, Volume 35, Issue 2, February 2026.
Abstract Isolating native ion channels for structural characterization is routinely achieved by extraction from membrane fractions of tissue with prolonged mild detergent treatment. AMPA receptors (AMPARs), glutamatergic receptors that mediate fast excitatory transmission and synaptic plasticity, are coassembled with diverse auxiliary subunits and ...
Jumi Park, Eric Gouaux
wiley   +1 more source

Difficult Closure of Open‐Window Thoracostomy After Drainage of an Infected Pulmonary Bulla

open access: yesRespirology Case Reports, Volume 14, Issue 2, February 2026.
This report describes an elderly man with an infected pulmonary bulla successfully treated with percutaneous drainage followed by open‐window thoracostomy (OWT) for persistent air leakage. Despite infection control, repeated failures of window closure occurred due to newly appearing bronchial fistulae.
Kazuki Sato   +3 more
wiley   +1 more source

Pathological fracture secondary to an aneurysmal bone cyst in the proximal femur of a 5‐year‐old French bulldog

open access: yesVeterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old, male, neutered French bulldog was referred with a 24‐hour history of left hindlimb lameness. The patient presented with a 9/10 grade left pelvic limb lameness and pain on full extension of the left hip joint. Radiographs, computed tomography and ultrasound‐guided fine needle aspirates were performed, leading to a presumptive ...
Carolyn Averil Hylton   +4 more
wiley   +1 more source

Selection for Function in Complex Distributed Pathological Systems

open access: yesEvolutionary Applications, Volume 19, Issue 2, February 2026.
ABSTRACT Pathological processes are often conceptualized as localized phenomena anchored in a primary tumor, a focal lesion, or a single organ. However, growing evidence indicates that many diseases persist and progress as complex distributed systems, maintained by interactions among multiple sites.
Frédéric Thomas   +9 more
wiley   +1 more source

GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis

open access: yesHistopathology, Volume 88, Issue 3, Page 698-709, February 2026.
We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Fatime Szalai   +6 more
wiley   +1 more source

Practice Guidelines for the Diagnosis and Treatment of Subepithelial Lesion Observed in Upper Gastrointestinal Endoscopy

open access: yesJournal of Gastroenterology and Hepatology, Volume 41, Issue 2, Page 488-501, February 2026.
ABSTRACT Subepithelial lesions (SELs) of the upper gastrointestinal tract are commonly detected during endoscopic examinations and encompass a broad spectrum of benign, potentially malignant, and malignant tumors. While most SELs are asymptomatic and incidentally found, accurate diagnosis remains challenging due to their subepithelial location ...
Beom Jin Kim   +17 more
wiley   +1 more source

Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism. [PDF]

open access: yesJ Cell Biol
Byrd A   +6 more
europepmc   +1 more source

Foreign Body Granuloma and Infection‐Related Complications Arising From Acupoint Embedding: A Case Study and Literature Review

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Acupoint embedding (AEM) therapy merges traditional acupuncture with modern biomaterials to treat various diseases and for cosmetic uses, especially obesity and facial anti‐aging. Research Objective To examine complications from acupuncture embedding therapy (AEM), focusing on foreign body granulomas and infections.
Xiazhen Xu   +4 more
wiley   +1 more source

Zweikanal‐Fluoreszenz‐Assays mit supramolekularen Wirt/Farbstoff‐Reporterpaaren zur Kartierung der Membranaktivität von Peptiden

open access: yesAngewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Membranaktive Peptide (MAPs) wie zellpenetrierende Peptide (CPPs) und antimikrobielle Peptide (AMPs) können Lipidmembranen durchdringen und Membranporen bilden. Die Kombination aus einem Farbstoff‐Efflux‐Assay und einem supramolekularen Tandem‐Membran‐Assay in einem Zweikanalformat ermöglicht eine fortgeschrittene mechanistische Charakterisierung und ...
Mohammad A. Alnajjar   +8 more
wiley   +1 more source

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