Results 111 to 120 of about 41,746 (235)

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Ecosystem retrogression enhances cross‐domain microbial stability and increases the genetic potential for nutrient cycling

mLife, EarlyView.
Abstract Ecosystem retrogression drives nutrient depletion, reduced productivity, and profound reorganization of soil microbial communities. Using amplicon sequencing and genome‐resolved metagenomics, we examined how cross‐domain microbial networks and functional gene potential respond to long‐term phosphorus and nitrogen limitation along the well ...
Javier A. Ceja‐Navarro, Dishant Patel, Garret Genco, Alyssa Byer, Daliang Ning, Kenneth H. Wan, Susan E. Celniker, Jizhong Zhou, Paul Dijkstra, Bruce A. Hungate, Jennifer Pett‐Ridge, Eoin L. Brodie   +11 more
wiley   +1 more source

Interplanetary frontiers: terraforming from an invasion science perspective

Oikos, EarlyView.
The pursuit of a multi‐planetary existence represents one of humanity's greatest frontiers. If applied justly, it offers an opportunity to extend its civilization's lifespan amid escalating sustainability crises on Earth. One approach increasingly gaining traction is terraforming, a hitherto theoretical ecological and evolutionary experiment revolving ...
Teun Everts, Ronaldo Sousa, Phillip J. Haubrock   +2 more
wiley   +1 more source

Urban wild meat and pangolin consumption across southern forested Cameroon: The limited influence of COVID‐19

People and Nature, EarlyView.
Abstract Overexploitation of wildlife is pervasive in many tropical regions, and in addition to being a significant conservation and sustainability concern, it has received global attention given discussions over the origins of zoonotic disease outbreaks.
Franklin T. Simo, Ghislain F. Difouo, Christian N. Tchana, Alain Christel Wandji, Alfiery Laurel Djomnang‐Nkwala, Marcelle Mbadjoun Nziké, Sévilor Kekeunou, Markéta Swiacká, Daniel J. Ingram   +8 more
wiley   +1 more source

Rounded Monodisperse Fluorescent Nanodiamonds

Small, EarlyView.
Nanodiamond (ND) shape control using rapid molten‐nitrate etching is studied as a scale‐up method for monodispersed rounded particles. Optimal etching condition (567°C for 6 min) yields NDs with atomically stepped surfaces and reduced sp2 content. Compared to angular control, rounded NDs exhibit an increased proportion of luminescent particles (66% vs.
Helena Raabova, Ivan Rehor, Jan Havlik, Stuart Turner, Jan Stursa, Vladimira Petrakova, Michal Gulka, Petr Cigler   +7 more
wiley   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Direct deposition on pre‐cooled grids: a new approach to sub‐millisecond cryoEM grid preparation

Acta Crystallographica Section D, EarlyView.
We describe a new method to prepare grids for cryoEM on the sub‐millisecond timescale.There has been a rapid expansion in new approaches to sample preparation for single‐particle cryoEM. One drive has been around speeding up the process both for the application of time‐resolved studies and in outrunning some of the negative effects which may come from ...
David P. Klebl, Robert W. Kay, Sean McMillan, Frank Sobott, Nikil Kapur, Stephen P. Muench   +5 more
wiley   +1 more source

Mycobacterium intracellulare M.i.198—A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM‐PD)

Microbiology and Immunology, EarlyView.
ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi, Ryoji Maekura, Yukiko Nishiuchi, Sohkichi Matsumoto   +3 more
wiley   +1 more source

EVICT, NEGLECT, OR INVEST? Community Power and the Politics of Urban Informality Governance in Jakarta

International Journal of Urban and Regional Research, EarlyView.
Abstract Why do some informal neighborhoods receive public investment while others are neglected or evicted? This article addresses the inconsistent governmental responses to informal settlements in Jakarta, Indonesia, during the democratic period. State actions range from violent evictions to tolerance and community‐led improvements.
Kadek Wara Urwasi
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source