Results 81 to 90 of about 41,746 (235)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Multiple evolutionary origins of giant viruses [version 1; referees: 4 approved]

F1000Research, 2018
The nucleocytoplasmic large DNA viruses (NCLDVs) are a monophyletic group of diverse eukaryotic viruses that reproduce primarily in the cytoplasm of the infected cells and include the largest viruses currently known: the giant mimiviruses, pandoraviruses,
Eugene V. Koonin, Natalya Yutin
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Haptophyte-infecting viruses change the genome condensing proteins of dinoflagellates

Communications Biology
Giant viruses are extraordinary members of the virosphere due to their structural complexity and high diversity in gene content. Haptophytes are ecologically important primary producers in the ocean, and all known viruses that infect haptophytes are ...
Haina Wang, Lingjie Meng, Sara Otaegi-Ugartemendia, Gabriela Nérida Condezo, Romain Blanc-Mathieu, Runar Stokke, Marius Rydningen Langvad, David Brandt, Jörn Kalinowski, Håkon Dahle, Carmen San Martín, Hiroyuki Ogata, Ruth-Anne Sandaa   +12 more
doaj   +1 more source

The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea

eLife, 2018
Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of ...
Christoph M Deeg, Cheryl-Emiliane T Chow, Curtis A Suttle   +2 more
doaj   +1 more source

Recent advances in multifunctional soft robots: A materials–structures–systems co‐design perspective for synergistic integration

FlexMat, EarlyView.
Abstract Soft robots, engineered from highly compliant materials, offer superior adaptability and safety in unstructured environments compared to their rigid counterparts. Recent advancements, fueled by bio‐inspiration and material programmability, have led to the rapid co‐evolution of their core modules: actuation, sensing, protection, energy, and ...
Qiulei Liu, Zicao Peng, Chong Sun, Haitao Yang   +3 more
wiley   +1 more source

Eagle's Syndrome Presenting With Peripheral Facial Palsy—A Case Report

Head &Neck, EarlyView.
ABSTRACT Background Eagle's syndrome is a condition caused by an elongated styloid process and is characterized by various symptoms such as cervicofacial pain, foreign body sensation, headache, odynophagia, and otalgia. However, the occurrence of a unilateral peripheral facial palsy as a symptom of Eagle's syndrome has been described only rarely ...
Vincent Holtmann, Roman Ackermann, Klaus Jahn, John‐Martin Hempel   +3 more
wiley   +1 more source

Association of Varicella Zoster Virus with Giant Cell Arteritis [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2014
Among the many scientific interests of Hilary Koprowski, I believe he was most excited by the possibility that multiple sclerosis (MS) was caused by a virus. Although our close collaboration from 1971 to 1985 did not reveal an association between MS and a virus, if HK (as we affectionately called him) were alive today, I am sure he would be equally ...
openaire   +2 more sources

Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes

Frontiers in Microbiology, 2018
Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named ‘TRUC’ (for “Things Resisting Uncompleted Classifications”) alongside Bacteria ...
Philippe Colson, Anthony Levasseur, Bernard La Scola, Vikas Sharma, Vikas Sharma, Arshan Nasir, Arshan Nasir, Pierre Pontarotti, Pierre Pontarotti, Gustavo Caetano-Anollés, Didier Raoult   +10 more
doaj   +1 more source