Results 61 to 70 of about 2,070,727 (280)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes

Frontiers in Microbiology, 2018
Giant viruses of amoebae were discovered in 2003. Since then, their diversity has greatly expanded. They were suggested to form a fourth branch of life, collectively named ‘TRUC’ (for “Things Resisting Uncompleted Classifications”) alongside Bacteria ...
Philippe Colson, Anthony Levasseur, Bernard La Scola, Vikas Sharma, Vikas Sharma, Arshan Nasir, Arshan Nasir, Pierre Pontarotti, Pierre Pontarotti, Gustavo Caetano-Anollés, Didier Raoult   +10 more
doaj   +1 more source

Brain tumors induced in rats by human adenovirus type 12 [PDF]

, 1974
Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu　strains were injected intracranially with human adenovirus type 12.　The incidence of intracranial tumors was 91% (30/33) in
Matsuo, Keisuke, Murao, Tsuyoshi, Ogawa, Katsuo, Ohmori, Hiroyuki, Sonobe, Hiroshi, Tsutsumi, Akira   +5 more
core   +1 more source

Quantitative Infection Dynamics of Cafeteria Roenbergensis Virus

Viruses, 2018
The discovery of giant viruses in unicellular eukaryotic hosts has raised new questions on the nature of viral life. Although many steps in the infection cycle of giant viruses have been identified, the quantitative life history traits associated with ...
Bradford P. Taylor, Joshua S. Weitz, Corina P. D. Brussaard, Matthias G. Fischer   +3 more
doaj   +1 more source

The Secret Life of Giant Viruses in the California Current

mSystems, 2021
In the last few decades, the virology field has experienced a revolution in knowledge related to viral richness, diversity, and distribution in the oceans.
Jônatas Santos Abrahão
doaj   +1 more source

Learning the diversity of giant viruses [PDF]

Nature Methods, 2020
Researchers identify a broad phylogenetic diversity of nucleocytoplasmic large DNA viruses by mining global-scale metagenomics datasets.
openaire   +2 more sources

Evidence for diversifying selection of genetic regions of encoding putative collagen-like host-adhesive fibers in Pasteuria penetrans [PDF]

, 2019
© FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided ...
Anderson, Andrews, Arohi Srivastava, Arslan, Atibalentja, Aziz, Carver, Charles, Cohan, Colson, Davies, Davies, Davies, Davies, Davies, Davies, Degnan, DePristo, Duan, Dutta, Eardly, Espanol, Felsenstein, Filée, Gascuel, Giblin-Davis, Giblin-Davis, Huynen, Jones, Kanehisa, Kaufman, Keith G Davies, Kumar, Legendre, Luijckx, Luijckx, Maddison, Mauchline, McElroy, Metchnikoff, Mohan, Mohan, Mouton, Murtagh, Noel, Philippe, R Developement Core Team, Radó-Trilla, Rajendhran, Romero, Rutherford, Sayre, Sayre, Schouls, Sharad Mohan, Sharma, Stackebrandt, Starr, Steichen, Stirling, Stirling, Sturhan, Sylvestre, Sylvestre, Tamura, Tim H Mauchline, Todd, Wiedenbeck, Woese, Yap, Zilversmit   +70 more
core   +3 more sources

Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses

Nature Communications, 2020
The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear.
M. Moniruzzaman, C. Martinez-Gutierrez, Alaina R. Weinheimer, F. Aylward   +3 more
semanticscholar   +1 more source

Giant viruses of the Megavirinae subfamily possess biosynthetic pathways to produce rare bacterial-like sugars in a clade-specific manner

microLife, 2022
The recent discovery that giant viruses encode proteins related to sugar synthesis and processing paved the way for the study of their glycosylation machinery. We focused on the proposed Megavirinae subfamily, for which glycan-related genes were proposed
A. Notaro, O. Poirot, E. Garcin, Sébastien Nin, A. Molinaro, M. Tonetti, C. de Castro, C. Abergel   +7 more
semanticscholar   +1 more source

The DNA Methylation Landscape of Giant Viruses [PDF]

Nature Communications, 2019
AbstractDNA methylation is an important epigenetic mark that contributes to various regulations in all domains of life. Prokaryotes use it through Restriction-Modification (R-M) systems as a host-defense mechanism against viruses. The recently discovered giant viruses are widespread dsDNA viruses infecting eukaryotes with gene contents overlapping the ...
Sandra Jeudy, Sofia Rigou, Jean-Marie Alempic, Jean-Michel Claverie, Chantal Abergel, Matthieu Legendre   +5 more
openaire   +4 more sources