Results 81 to 90 of about 1,628,791 (312)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Problemas e tensões entre as noções de produção, propriedade intelectual e cultura
Horizontes Antropológicos, 2012 Neste artigo, analiso as relações entre as noções de produção, propriedade intelectual e cultura. Partindo das articulações entre inventor e invenção, mostro quais caminhos problematizam a categoria da propriedade intelectual, sublinhando dualidades do ...
Guilherme Francisco Waterloo Radomsky
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
“Mais vint un second jour”. Pour Yves Bonnefoy
Lea, 2016 This short article intends to honour the poet Yves Bonnefoy who died recently. His “passing away” as a perpetual movement seems to confirm his poetics of presence which he had been evoking throughout his life.
Michela Landi
doaj +1 more source
Peer effects, risk pooling, and status seeking: What explains gift spending escalation in rural China? [PDF]
It has been widely documented that the poor spend a significant proportion of their income on gifts even at the expense of basic consumption. We test three competing explanations of this phenomenon—peer effect, status concern, and risk pooling—based on a
Chen, Xi, Kanbur, Ravi, Zhang, Xiaobo
core
Teaching Writers How to Write [PDF]
, 2012 Anna Keesey, acclaimed author of Little Century, shares her knowledge and gift for language with budding young ...
Mileham, Mardi
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
On the Feasibility of Power and Status Ranking in Traditional Setups [PDF]
This paper aims at a better understanding of the conditions under which unequal rank or power positions may get permanently established through asymmetric gift exchange when a gift brings pride to the donor and shame to the recipient.
Jean-Philippe Platteau, Petros Sekeris
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Rethinking the Penalty for the Failure to File Gift Tax Returns [PDF]
, 2013 In this article, the authors argue that Congress must reform the penalty structure associated with the failure to file gift tax returns if it wants to maintain the integrity of the transfer tax ...
Caron, Paul L. +3 more
core +1 more source