Results 51 to 60 of about 1,143,701 (190)

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions [PDF]

Clin Pharmacol Ther
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Krohmer E, König M, Vogt C, Streckebein M, Baumann S, Blumenstock M, Böhm R, Müller F, Struß N, Wurmbach V, Blank A.   +10 more
europepmc   +2 more sources

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

The State of the Art in Visualization Literacy

Computer Graphics Forum, EarlyView.
In this survey paper, we review 385 visualization literacy papers to understand the state of the field. We discuss 5 different types of research contributions, as well as 4 competency themes that capture the skills relevant to visualization literacy. Abstract Research in visualization literacy explores the skills required to engage with visualizations.
Matthew Varona, Karen Bonilla, Maryam Hedayati, Alark Joshi, Matthew Kay, Lane Harrison, Carolina Nobre   +6 more
wiley   +1 more source

Perioperative management and anaesthetic considerations for adult patients with Gilbert’s syndrome and oral cancer: review and case report

Biotechnology & Biotechnological Equipment, 2019
Gilbert’s syndrome is the most common cause of hereditary hyperbilirubinemia and poses a clinical challenge for anaesthesiologists. The decreased activity of bilirubin uridine glucuronyl transferase can lead to toxicity for usual doses of most ...
Dochka Tzoneva, Evgeniy Aleksiev, Kalina Michova, Pavel Stanimirov   +3 more
doaj   +1 more source

Larval character evolution in Holometabola (Insecta)

Cladistics, EarlyView.
Abstract Larvae, a novel type of immature stage, are a crucial innovation of the Holometabola. Larval features therefore provide key evidence for reconstructing evolutionary transformations in this megadiverse group. Here we present the first formal reconstruction of larval character evolution, using maximum parsimony and Bayesian ancestral‐state ...
Rolf Georg Beutel, Jakub Goczał, Di Li
wiley   +1 more source

Evidence for higher red blood cell mass in persons with unconjugated Hyperbilirubinemia and Gilbert's syndrome

, 2008
Background: The genetic polymorphism responsible from Gilbert's syndrome is not sufficient for the clinical phenotype to occur in many persons. Additional factors are believed to contribute in pathogenesis. Red cell mass may be such a factor. Methods: We
Akman, Umit, Shorbagi, Ali I., BÜYÜKAŞIK, YAHYA, GÖKER, HAKAN, Kilicarslan, Alparslan, Hascelik, Gulsen, Buyukasik, Naciye S., HAZNEDAROĞLU, İBRAHİM CELALETTİN   +7 more
core   +1 more source

Diagnostic criteria and contributors to Gilbert’s syndrome [PDF]

Critical Reviews in Clinical Laboratory Sciences, 2018
Hyperbilirubinemia is a well-known condition in the clinical setting; however, the causes of elevated serum bilirubin are diverse, as are the clinical ramifications of this condition. For example, diagnoses of individuals vary depending on whether they exhibit an unconjugated or conjugated hyperbilirubinemia.
Wagner, Karl-Heinz, Shiels, Ryan G, Lang, Claudia Anna, Khoei, Nazlisadat Seyed, Bulmer, Andrew C   +4 more
openaire   +7 more sources

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Data from: Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: comparative study

, 2014
Objectives: The objective of our follow-up study is to evaluate liver function tests (LFTs) and lipid profiles in patients with Gilbert's syndrome treated with isotretinoin because of severe acne. Setting: Dermatology outpatient clinics of three regional
Navajas, Rafael Fernández-Crehuet, Fernández-Crehuet, José Luis, Fernández-Crehuet, Pablo, Allam, Mohamed Farouk   +3 more
core   +1 more source

Gilbert’s Syndrome: Terminology, Epidemiology, Genetics, Pathogenesis (Part I)

Zdorovʹe Rebenka, 2016
The aim of the review was the analysis of the literature about the prevalence, etiology, genetics and pathogenesis of Gilbert’s syndrome (GS). The scientific literature regarding GS with the keywords «Gilbert's syndrome», «hyperbilirubinemia», «uridine ...
T.V. Sorokman, O.-M.V. Popeliuk, O.V. Makarova   +2 more
doaj   +1 more source