Results 1 to 10 of about 479 (109)

Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2020
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However, several clinical studies have revealed an enrichment of P. gingivalis in the stool samples and colorectal mucosa of colorectal cancer patients.
Wenxin Mu, Yiqun Jia, Xiaobing Chen, Haoyu Li, Zhi Wang, Bin Cheng   +5 more
doaj   +1 more source

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

FEBS Letters, 1998
We show by site‐directed mutagenesis that the catalytic residues of mammalian legumain, a recently discovered lysosomal asparaginycysteine endopeptidase, form a catalytic dyad in the motif His‐Gly‐spacer‐Ala‐Cys. We note that the same motif is present in the caspases, aspartate‐specific endopeptidases central to the process of apoptosis in animal cells,
Chen, Jinq-May, Rawlings, Neil D., Stevens, Richard A.E., Barrett, Alan J.   +3 more
openaire   +2 more sources

Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains. [PDF]

Microbiologyopen, 2023
Haugsten HR, Kristoffersen AK, Haug TM, Søland TM, Øvstebø R, Aass HCD, Enersen M, Galtung HK.   +7 more
europepmc   +1 more source

Production and properties of adhesin-free gingipain proteinase RgpA. [PDF]

Sci Rep, 2023
Mahmud ASM, Seers CA, Huq NL, Zhang L, Butler CA, Moore C, Cross KJ, Reynolds EC.   +7 more
europepmc   +1 more source

A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis. [PDF]

Angew Chem Int Ed Engl, 2022
Moore C, Cheng Y, Tjokro N, Zhang B, Kerr M, Hayati M, Chang KCJ, Shah N, Chen C, Jokerst JV.   +9 more
europepmc   +1 more source

Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome-lysosome fusion. [PDF]

Int J Oral Sci, 2023
Shiheido-Watanabe Y, Maejima Y, Nakagama S, Fan Q, Tamura N, Sasano T.   +5 more
europepmc   +1 more source

Computational Study of the Inhibition of RgpB Gingipain, a Promising Target for the Treatment of Alzheimer's Disease. [PDF]

J Chem Inf Model, 2023
Movilla S, Martí S, Roca M, Moliner V.
europepmc   +1 more source

COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease. [PDF]

Expert Opin Investig Drugs, 2022
Sabbagh MN, Decourt B.
europepmc   +1 more source

OmpA_C-Like Domain of PorE Is Essential for PorE Function in the Type IX Secretion System (T9SS) of Porphyromonas gingivalis and Some T9SS Cargo Proteins Are Secreted in a PorE-Independent Manner. [PDF]

Microbiol Immunol
Tominaga T, Yukitake H, Veith PD, Gorasia DG, Ayuse T, Sanuki T, Reynolds EC, Nakayama K, Naito M, Shoji M.   +9 more
europepmc   +1 more source

Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. [PDF]

mBio, 2022
Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J.   +10 more
europepmc   +1 more source