Results 11 to 20 of about 479 (109)

Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2 [PDF]

The FEBS Journal, Volume 280, Issue 11, Page 2608-2621, June 2013., 2013
Metacaspases play an important role in the life cycle of trypanosomes and their absence in humans makes them attractive drug targets. Here we use detailed kinetic, biochemical and structural analyses to investigate the substrate specificity and effects of Ca2+ on the activation of metacaspase 2 from Trypanosoma brucei.
Maurício F. M. Machado, Marcelo F. Marcondes, Maria A. Juliano, Karen McLuskey, Jeremy C. Mottram, Catherine X. Moss, Luiz Juliano, Vitor Oliveira   +7 more
wiley   +3 more sources

The Role of Proteinase‐Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease [PDF]

Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Proteinase‐activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial enzymes.
E. S. Rovai, M. Holzhausen, Kristen M. Kahle   +2 more
wiley   +4 more sources

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease. [PDF]

J Intern Med
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Barron AE, Lin JS, Ryder MI, Bergman P.
europepmc   +2 more sources

Insights Into the Mechanism of Action of Chlorhexidine on <i>Porphyromonas gingivalis</i>. [PDF]

Int J Dent
Chlorhexidine (CHX) remains the most effective antiseptic in periodontal therapy, multiple reports have identified ultrastructural antibacterial effects of CHX on oral bacteria, however, little is known about its molecular mechanism of action on Porphyromonas gingivalis, an important pathobiont directly associated with the pathogenesis of periodontitis.
Mejía K, Rodríguez-Hernández AP, Martínez-Hernández M.   +2 more
europepmc   +2 more sources

Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis   +3 more
wiley   +1 more source

A diverse uncultivated microbial community is responsible for organic matter degradation in the Black Sea sulphidic zone

Environmental Microbiology, Volume 23, Issue 6, Page 2709-2728, June 2021., 2021
Summary Organic matter degradation in marine environments is essential for the recycling of nutrients, especially under conditions of anoxia where organic matter tends to accumulate. However, little is known about the diversity of the microbial communities responsible for the mineralization of organic matter in the absence of oxygen, as well as the ...
Saara Suominen, Nina Dombrowski, Jaap S. Sinninghe Damsté, Laura Villanueva   +3 more
wiley   +1 more source

Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

Molecular Oral Microbiology, Volume 36, Issue 2, Page 145-156, April 2021., 2021
Abstract Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are ...
Takayuki K. Nemoto, Yuko Ohara Nemoto
wiley   +1 more source

Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases. [PDF]

, 2016
Porphyromonas gingivalis (Pg) is a keystone pathogen in the aetiology of chronic periodontitis. However, recent evidence suggests that the bacterium is also able to enter the bloodstream, interact with host cells and tissues, and ultimately contribute to
A Haraguchi, A Singh, AH Meijer, AL Griffen, AM Louhelainen, AM van der Sar, BM Hogan, BR Dorn, BR Dorn, CA Genco, CO Igboin, D Grenier, DM Castillo, EV Kozarov, G Hajishengallis, G Hajishengallis, G Hajishengallis, H Inaba, IM Velsko, J Potempa, J Potempa, J Slots, JT Singer, K Wada, KA Nguyen, KE Nelson, KJ Clark, KJ Maresz, L Li, L Reyes, M Benedyk, M Hashimoto, M Rapala-Kozik, M Sztukowska, MK Brannon, ML Laine, NE Fiehn, PR Blackburn, RC Williams, RG Deshpande, SM Sheets, SM Sheets, T Abe, T Imamura, T Kadowaki, TD Herath, TK Prajsnar, TK Prajsnar, TR Mikuls, VI Haraszthy, Y Guo, Y Kumagai   +51 more
core   +2 more sources

Bradykinin – An elusive peptide in measuring and understanding

, 2022
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 2, February 2022.
Alessandro S. Pinheiro, Sadiq Silbak, Alvin H. Schmaier   +2 more
wiley   +1 more source

Papain-like proteases: Applications of their inhibitors [PDF]

, 2010
Proteases are one of the most important classes of enzyme and expressed throughout the animal and plant kingdoms as well as in viruses and bacteria.
Dubey, VK, Jagannadham, MV, Pande, M, Singh, BK   +3 more
core   +2 more sources