Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades [PDF]
Comparative genomic analyses are powerful tools that can be used to analyze the presence, conservation, and evolution of protein families and to elucidate issues concerning their function.
Abascal +62 more
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Synthesis of Sphingolipids Impacts Survival of Porphyromonas gingivalis and the Presentation of Surface Polysaccharides [PDF]
Bacteria alter the biophysical properties of their membrane lipids in response to environmental cues, such as shifts in pH or temperature. In essence, lipid composition determines membrane structure, which in turn influences many basic functions, such as
Floyd Dewhirst +5 more
core +2 more sources
Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor [PDF]
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Guevara, Tibisay +6 more
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MicroED structure of the C11 cysteine protease clostripain. [PDF]
Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family of Clan CD cysteine peptidases, which is an important group of peptidases secreted by numerous bacteria.
Ruma YN, Bu G, Hattne J, Gonen T.
europepmc +3 more sources
Identification of Dipeptidyl-Peptidase (DPP)5 and DPP7 in Porphyromonas endodontalis, Distinct from Those in Porphyromonas gingivalis [PDF]
Dipeptidyl peptidases (DPPs) that liberate dipeptides from the N-terminal end of oligopeptides are crucial for the growth of Porphyromonas species, anaerobic asaccharolytic gram negative rods that utilize amino acids as energy sources.
A Banbula +50 more
core +5 more sources
Are metacaspases caspases? [PDF]
The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its
Declercq, Wim +3 more
core +3 more sources
Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent [PDF]
Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus.
Díaz Zúñiga, Jaime +9 more
core +1 more source
Levels of and especially the degree of activation of matrix metalloproteinase (MMP‐8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri‐implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri‐implant diseases.
Ahmed Al-Majid +6 more
wiley +1 more source
Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay [PDF]
Recent advances in understanding the dynamic pathways involved in the pathogenesis of rheumatoid arthritis have emphasized the pivotal role of pro-inflammatory cytokines, inflammatory cells, endothelial cell activation and matrix degradation, acting in a
Ancuta, Codrina +3 more
core +2 more sources
Identification and Characterization of Prokaryotic Dipeptidyl-Peptidase 5 from Porphyromonas gingivalis [PDF]
Porphyromonas gingivalis, a Gram-negative asaccharolytic anaerobe, is one of the major causative organisms of chronic periodontitis. The bacterium utilizes amino acids as energy and carbon sources, and incorporates them mainly as dipeptides. Therefore, a
Ahrén +47 more
core +2 more sources

