Results 41 to 50 of about 836,914 (213)

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Molecular and cellular mechanisms of Ginkgo biloba extract [EGb 761®] in improving age-related and ß-amyloid induced neuronal dysfunctions [PDF]

, 2009
The utilization of Ginkgo biloba in medicinal practice dates back to 1505 A.D. Ironically, the mechanisms of action of Ginkgo are not fully clarified till now.
Abdel-Kader, Reham Mahmoud
core  

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks

Frontiers in Pharmacology, 2018
Background: Details of the extraction and purification procedure can have a profound impact on the composition of plant-derived extracts, and thus on their efficacy and safety.
Benjamin M. Bader, Konstantin Jügelt, Luise Schultz, Olaf H.-U. Schroeder   +3 more
doaj   +1 more source

Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761) [PDF]

, 2006
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue.
Schindowski, Katharina, Leutner, Silke, Eckert, Anne, Kreßmann, Sabine, Müller, Walter E.   +4 more
core  

Otoproteção em cobaias expostas a agrotóxico e ginkgo biloba Otoprotection in guinea pigs exposed to pesticides and ginkgo biloba

Brazilian Journal of Otorhinolaryngology, 2012
Os agrotóxicos são amplamente utilizados na agricultura e, atualmente, fazem parte do grupo de agentes químicos que podem levar à perda auditiva. A identificação de drogas que, associadas aos ototóxicos, possam atuar como otoprotetores é objeto de estudo.
Andréa Dulor Finkler, Aron Ferreira da Silveira, Gisiane Munaro, Crisley Dossin Zanrosso   +3 more
doaj   +1 more source

Large language models unlock large text corpora in the search for data on medicinal plants and fungi

PLANTS, PEOPLE, PLANET, EarlyView.
Millions of people worldwide depend on plants and fungi for their healthcare needs, yet our understanding of which species are used medicinally—and how—remains fragmented and incomplete. As part of Kew's Plants for Health service, we developed a pipeline to mine large text corpora for information on natural products, initially focusing on the medicinal
Adam Richard‐Bollans, Francesco Civita, Tiziana A. Cossu, Ifra Saifi, Kristina Patmore, Caroline Wilkinson, Bob Allkin   +6 more
wiley   +1 more source

WorldCuP: A database of checklists documenting the World's Cultivated Plants and their distributions

PLANTS, PEOPLE, PLANET, EarlyView.
Human life would be unrecognizable without the benefits of cultivated plants, including crops, ornamentals, or plants with other uses. Despite their importance in daily life and prevalence across landscapes, we know surprisingly little about global cultivated plant distributions.
Nicole L. Kinlock, Amy J. S. Davis, Mark van Kleunen   +2 more
wiley   +1 more source

Function, biosynthesis, and regulation mechanisms of flavonoids in Ginkgo biloba

Fruit Research, 2023
Ginkgo biloba is an important economic tree species. Due to the abundance of secondary metabolites in the tree, Ginkgo biloba extract (GbE) is used as a medicine, food supplement, and nutraceutical. Flavonoids are the most active components in GbE. There
Danyang Mao, Lei Zhong, Xiya Zhao, Li Wang   +3 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source