Results 51 to 60 of about 17,389 (225)

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine [PDF]

, 2016
published_or_final_versio
Chan, SW, Cui, G, Hoi, MPM, Kwan, YW, Lee, SMY, Leung, GPH, Tseng, HHL, Zhou, X   +7 more
core   +1 more source

Enabling the study of gene function in gymnosperms: Virus‐induced gene silencing in Ephedra tweedieana

Applications in Plant Sciences, EarlyView.
Abstract Premise As the sister clade to angiosperms, extant gymnosperms are crucial for reconstructing ancestral gene regulatory networks in seed plants. This highlights the need for model systems representing each of their distinct lineages. However, tools to quickly and effectively investigate gene function in gymnosperms are still limited due to the
Anthony G. K. Garcia, Jo Trang Bùi, Todd P. Michael, Stefanie M. Ickert‐Bond, Verónica S. Di Stilio   +4 more
wiley   +1 more source

Ginkgo Biloba

JACC: Case Reports, 2020
Ginkgo biloba is a commonly used herbal supplement in the United States. We describe a 63-year-old man with a significant ventricular ectopic burden (32.7%) that was refractory to metoprolol tartrate (41.7%) and resolved (
Sami J. Natour, MD, Sarah J. Goldberg, NP, Evangelos A. Diamantakos, DO, Janet K. Han, MD   +3 more
doaj   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts [PDF]

, 2002
The aim of this study is to investigate the effects of Panax quinquefolius L. extract (PQE), Ginkgo biloba extract (GBE), and Hypericum perforatum extract (HPE), in combination or alone, on the survival and regeneration of axotomized retinal ganglion ...
Chen, CF, Cheung, ZH, Lu, Q, Pang, PKT, Shan, JJ, So, KF, Wu, W, Yip, HK   +7 more
core   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Conservation status of species used in the UK herbal medicine industry

PLANTS, PEOPLE, PLANET, EarlyView.
Given the ongoing biodiversity crisis, sustainable use and management of medicinal plants is critical. We assessed the conservation status, threats and conservation actions of 298 species sold by UK suppliers to medical herbalists. We found that most species used are unevaluated, representing a gap in conservation knowledge, and of those with ...
Isabella Flowers, Jon C. Lovett, Christopher Hassall   +2 more
wiley   +1 more source

The effect of twelve weeks of high-intensity functional training and Ginkgo biloba consumption on the serum levels of some inflammatory cytokines in operational male firefighters of Yazd city [PDF]

طب کار
Introduction: functional exercises and consumption of the medicinal plant Ginkgo biloba, a natural source of flavonoids and polyphenolic compounds, have beneficial effects in improving the inflammatory state and physical performance of people exposed to ...
Hamid Sedaghat, Farzaneh Taghian, Khosro Jalali Dehkordi, hasan naghizadeh   +3 more
doaj  

Permitted daily exposure from preclinical studies of Ginkgo biloba L. dry extract

Brazilian Journal of Pharmaceutical Sciences, 2023
Resolution 658/2022 of the Brazilian Regulatory Agency requires the determination of the permitted daily exposure (PDE) of pharmaceutical agents. Ginkgo biloba L. is used therapeutically to treat memory deficits and other brain diseases.
Liliane Weber Bolfe Lamb, Gabriela Zimmermann Prado Rodrigues, Thalia Emmanoella Sebulsqui Saraiva, Douglas de Souza, Gabriel da Costa Berna, Ana Letícia Hilário Garcia, Fernando Bertoldi de Oliveira, Juliana Machado Kayser, Andriele Veiverberg, Mariana Roza Marco, Giulia Aline Führ, Günther Gehlen, Andresa Heemann Betti, Cristiane Bastos de Mattos   +13 more
doaj   +1 more source