Results 271 to 280 of about 51,810 (321)

Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K/Akt/mTOR Signaling Pathway and Reduces Myocardial Ischemia/Reperfusion Injury.

The American Journal of Chinese Medicine, 2021
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage in acute myocardial infarction, and its treatment remains a clinical challenge.
Guo-Wei Qin, Pan Lu, Li Peng, Wei Jiang
semanticscholar   +1 more source

Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway.

The American Journal of Chinese Medicine, 2022
Carbon tetrachloride (CCl4)-induced lipid peroxidation associated with hepatic oxidative stress and cell death is an important mechanism of acute liver injury (ALI). Ginsenoside Rd is considered an active ingredient of ginseng.
Yuangeng Li, Ping Yu, Wenwen Fu, Shuo Wang, Wenjun Zhao, Yue Ma, Yi Wu, Heming Cui, Xiaofeng Yu, L. Fu, Huali Xu, Dayun Sui   +11 more
semanticscholar   +1 more source

Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease.

Journal of Agricultural and Food Chemistry, 2022
Alcoholic liver disease (ALD) is a serious worldwide health problem. Ginsenoside Rc is a major active ingredient isolated from Panax ginseng, whose pharmacological effects counteract oxidative stress, inflammation, and lipid accumulation.
Zhisen Pan, Jingyi Guo, Kaijia Tang, Yanling Chen, Xun Gong, Ying Chen, Yadi Zhong, Xuesu Xiao, Siwei Duan, Tianqi Cui, Xiumei Wu, Yanhua Zhong, Xiaoying Yang, Chuangpeng Shen, Yong Gao   +14 more
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Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis.

Journal of Integrative Plant Biology, 2022
The ginsenoside Rg3 found in Panax species has extensive pharmacological properties, in particular anti-cancer effects. However, its natural yield in Panax plants is limited.
L. Yao, Huanyu Zhang, Yirong Liu, Qiushuang Ji, Jing Xie, Ru Zhang, Luqi Huang, Kunrong Mei, Juan Wang, Wenyuan Gao   +9 more
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Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats.

Journal of food biochemistry, 2022
Ginsenoside Rg1 is the active ingredient of the plant named genus Panax (ginseng), which exhibited significant bioactivities, including anti-inflammatory, antioxidation, and anti-diabetic effects.
Man Peng, Liming Wang, Hui Su, Lei Zhang, Yue Yang, Le Sun, Yi Wu, Lei Ran, Sida Liu, Mingxiao Yin, Shude Li, W. Chunyu   +11 more
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Mitochondrial connection to ginsenosides

Archives of Pharmacal Research, 2020
Mitochondria play an essential role in energy synthesis and supply, thereby maintaining cellular function, survival, and energy homeostasis via mitochondria-mediated pathways, including apoptosis and mitophagy. Ginsenosides are responsible for most immunological and pharmacological activities of ginseng, a highly beneficial herb with antioxidant, anti ...
Feng Wang, Yoon Seok Roh
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Ginseng Omics for Ginsenoside Biosynthesis

Current Pharmaceutical Biotechnology, 2021
Ginseng, also known as the king of herbs, has been regarded as an important traditional medicine for several millennia. Ginsenosides, a group of triterpenoid saponins, have been characterized as bioactive compounds of ginseng. The complexity of ginsenosides hindered ginseng research and development both in cultivation and clinical research. Therefore,
Xianmei Yin, Haoyu Hu, Xiaofeng Shen, Xiangyan Li, Jin Pei, Jiang Xu   +5 more
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Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Photochemistry and Photobiology, 2019
AbstractGinsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound‐Y (C‐Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB‐irradiated NHDFs and its potential for use as an antihyperpigmentation agent through ginsenoside C ...
Xiao‐yi Liu, Yong‐Kun Xiao, Eunson Hwang, Jeong Jee Haeng, Tae‐Hoo Yi   +4 more
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Conversion of Major Ginsenoside Rb1 to Ginsenoside F2 by Caulobacter leidyia

Biotechnology Letters, 2006
Ginsenoside Rb1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong beta-glucosidase-producing activity, converted ginsenoside Rb(1) to the active metabolites by 91%.
Le-Qin, Cheng, Myung Kyum, Kim, Jun-Won, Lee, Youn-Jin, Lee, Deok-Chun, Yang   +4 more
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Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway

Journal of Cellular Biochemistry, 2019
Sepsis‐induced myocardial dysfunction (SIMD) causes high mortality in seriously ill patients. Ginsenoside Rg1 has been proven to have effective anti‐inflammatory and antiapoptotic properties.
Man Luo, Dongsheng Yan, Qingsong Sun, Jia-Li Tao, Liang Xu, Hong Sun, Hongmei Zhao   +6 more
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